Brain inflammation has been implicated in the development of brain edema and secondary
brain damage in ischemia and trauma. Adhesion molecules, cytokines and leukocyte …

Stroke is a heterogeneous disease, and within the broad category of brain ischemia and its
subtypes vary dramatically in its etiology. The endothelium can regulate the vascular …

As summarized in Fig. 2, nearly all aspects of brain microvascular endothelial cell function
may be affected by ischemia. These alterations not only interfere with BBB functions which …

BACKGROUND: A growing number of recent investigations have established a critical role
for leukocytes in propagating tissue damage after ischemia and reperfusion in stroke …

Ischemic brain injury is exacerbated by leukocyte infiltration and formation of vasogenic
edema. In this study we demonstrate that intercellular adhesion molecule-1 (ICAM-1) is …

Background After focal brain ischemia, leukocytes adhere to the perturbed endothelium and
are believed to aggravate reperfusion injury. Although ischemia-induced upregulation of …

Ischemic stroke is a leading cause of death and disability in developed countries. Yet, in
spite of substantial research and development efforts, no specific therapy for stroke is …

There is increasing evidence that the inflammatory response plays an important role in CNS
ischemia. The murine model of focal ischemia, however, remains incompletely …

Inflammation has been implicated as a secondary injury mechanism following ischemia and
stroke. A variety of experimental models, including thromboembolic stroke, focal and global …

The possibility of reopening an occluded cerebral artery by means of thrombolysis has
renewed interest in a number of the several mechanisms that are active during acute …