Synovial fluid biomarkers in knee osteoarthritis: a systematic review and quantitative evaluation using BIPEDs criteria

A Boffa, G Merli, L Andriolo, C Lattermann… - Cartilage, 2021 - journals.sagepub.com
Objective The aim of this systematic review was to analyze the evidence about the efficacy of
the several synovial fluid (SF) biomarkers proposed for knee osteoarthritis (OA), categorizing …

[HTML][HTML] Expression of synovial fluid biomarkers in patients with knee osteoarthritis and meniscus injury

J Ding, X Niu, Y Su, X Li - … and Therapeutic Medicine, 2017 - spandidos-publications.com
In the present study, the levels of synovial fluid biomarkers of patients with knee
osteoarthritis (OA) and those with meniscus injury (MI) were compared to associate the …

[HTML][HTML] Synovial fluid biomarkers associated with osteoarthritis severity reflect macrophage and neutrophil related inflammation

CA Haraden, JL Huebner, MF Hsueh, YJ Li… - Arthritis research & …, 2019 - Springer
Background To identify a synovial fluid (SF) biomarker profile characteristic of individuals
with an inflammatory osteoarthritis (OA) endotype. Methods A total of 48 knees (of 25 …

Delineating the synovial fluid proteome: recent advancements and ongoing challenges in biomarker research

D Cretu, EP Diamandis, V Chandran - Critical reviews in clinical …, 2013 - Taylor & Francis
There is an urgent need for identifying novel serum biomarkers that can be used to improve
diagnosis, predict disease progression or response to therapy, or serve as therapeutic …

[HTML][HTML] Synovial fluid cytokines, chemokines and MMP levels in osteoarthritis patients with knee pain display a profile similar to many rheumatoid arthritis patients

RT Meehan, EA Regan, ED Hoffman, ML Wolf… - Journal of Clinical …, 2021 - mdpi.com
Background: There are currently no effective disease-modifying drugs to prevent cartilage
loss in osteoarthritis and synovial fluid is a potentially valuable source of biomarkers to …

Multi-omics analysis of synovial fluid: a promising approach in the study of osteoarthritis.

G Vicenti, D Bizzoca, M Carrozzo… - Journal of biological …, 2018 - europepmc.org
Osteoarthritis (OA), affecting 250 million individuals worldwide, is a significant social health
problem. Therefore, the search for synovial fluid (SF) biomarkers that could anticipate the …

Proteomic analysis of synovial fluid from the osteoarthritic knee: comparison with transcriptome analyses of joint tissues

SY Ritter, R Subbaiah, G Bebek, J Crish… - Arthritis & …, 2013 - Wiley Online Library
Objective The pathophysiology of the most common joint disease, osteoarthritis (OA),
remains poorly understood. Since synovial fluid (SF) bathes joint cartilage and synovium, we …

Identification of synovial fluid biomarkers for knee osteoarthritis and correlation with radiographic assessment

F Monibi, BL Roller, A Stoker, B Garner… - The Journal of Knee …, 2016 - thieme-connect.com
Osteoarthritis (OA) is a costly and debilitating condition that is typically not diagnosed early
enough to prevent progression of disease. The purpose of this study was to evaluate …

[HTML][HTML] The usefulness of synovial fluid proteome analysis in orthopaedics: focus on osteoarthritis and periprosthetic joint infections

D Bizzoca, L Moretti, A Gnoni, FL Moretti… - Journal of Functional …, 2022 - mdpi.com
Synovial fluid (SF) is a viscous and mucinous substance produced by the synovium, a
specialized connective tissue that lines diarthrodial joints. SF represents a source of disease …

[HTML][HTML] Towards precision medicine for osteoarthritis: focus on the synovial fluid proteome

L Moretti, D Bizzoca, A Geronimo, FL Moretti… - International Journal of …, 2022 - mdpi.com
Osteoarthritis (OA) is a joint degenerative disease that most affects old age. The study of
proteomics in synovial fluid (SF) has the task of providing additional elements to diagnose …