Mitochondria are potent producers of cellular superoxide, from complexes I and III of the
electron transport chain, and mitochondrial superoxide production is a major cause of the …

Superoxide activates nucleotide-sensitive mitochondrial proton transport through the
uncoupling proteins UCP1, UCP2, and UCP3 (Echtay, KS, et al.(2002) Nature 415, 1482 …

Mitochondria are a major source of superoxide, formed by the one-electron reduction of
oxygen during electron transport. Superoxide initiates oxidative damage to phospholipids …

According to the state of mitochondrial respiration, the respiratory chain generates
superoxide anions converted into hydrogen peroxide. Two uncoupling proteins (UCP) able …

The physiological functions of the mitochondrial uncoupling proteins (UCP2 and UCP3) are
still under debate. There is, however, ample evidence to indicate that, in contrast to UCP1 …

Mitochondria are the major cellular producers of reactive oxygen species (ROS), and
mitochondrial ROS production increases steeply with increased proton-motive force. The …

Reactive oxygen species (ROS), natural by-products of aerobic respiration, are important
cell signaling molecules, which left unchecked can severely impair cellular functions and …

The mitochondrial uncoupling proteins UCP2 and UCP3 may be important in attenuating
mitochondrial production of reactive oxygen species, in insulin signalling (UCP2), and …

Uncoupling proteins (UCP1, UCP2 and UCP3) are important in regulating cellular fuel
metabolism and as attenuators of reactive oxygen species production through strong or mild …

In thermogenic brown adipose tissue, uncoupling protein 1 (UCP1) catalyzes the dissipation
of mitochondrial proton motive force as heat. In a cellular environment of high oxidative …