Antitumor T lymphocytes play a pivotal role in immunosurveillance of malignancy. The CTL
antigen 4 (CTLA-4) is a vital negative regulator of T-cell activation and proliferation. This …

Accumulated evidence suggested that cytotoxic T-lymphocyte antigen 4 (CTLA4) plays an
important role in the negative regulation of T-cell proliferation and activation, and thus …

BACKGROUND: Polymorphisms in the cytotoxic T‐lymphocyte antigen 4 (CTLA‐4) gene
have been implicated in susceptibility to cancer, but the many published studies have …

Genetic polymorphisms in the human genome are an important component of genotypic
variability including one's immune status. Single nucleotide polymorphisms (SNPs) in the …

Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) is a potent immunoregulatory
molecule that downregulates T-cell activation and thus influences the antitumor immune …

Abstract Background and Aim: Cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4) is a potent
immunoregulatory molecule that suppresses antitumor response by down‐regulating T‐cell …

Background: Cytotoxic T-lymphocyte antigen-4 (CTLA-4) is a potent immunoregulatory
molecule that suppresses anti-tumor response by down-regulating T-cell activation. CTLA-4 …

Purpose Colorectal cancer (CRC) is one of the most common malignancies in the world and
a multipathway disease. Cytotoxic T-lymphocyte antigen-4 (CTLA-4) is a potent …

Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) was widely accepted as a pivotal
molecule in downregulating T-cell mediated immune responses. In this study we …

BACKGROUND: Antitumor T lymphocytes play an essential part in immune surveillance of
cancer cells. Cytotoxic T lymphocyte–associated Protein 4 (CTLA‐4) is a negative regulator …