In addition to their classical role in ATP generation, mitochondria also contribute to Ca2+
buffering, free radical production, and initiation of programmed cell death. Mitochondrial …

Mitochondria-targeting has become a major tool in the field of cancer treatment. We
demonstrate how the positively charged targeting moieties can be exploited to achieve …

The importance of mitochondrial delivery of an anticancer drug to cancer cells has been
recognized to improve therapeutic efficacy. The introduction of lipophilic cations, such as …

Context: Nanocarrier-based strategies to achieve delivery of bioactives specifically to the
mitochondria are being increasingly explored due to the importance of mitochondria in …

Mitochondrion-orientated transportation of smart liposomes has been developed as a
promising strategy to deliver anticancer drugs directly to tumor sites, and these have a …

Any variation in normal cellular function results in mitochondrial dysregulation that occurs in
several diseases, including cancer. Such processes as oxidative stress, metabolism …

The mitochondria are a dynamic powerhouse organelle that contributes greatly to cancer
therapy. Solving the current problems that occur mostly in chemotherapy and diagnosis of …

Mitochondrial-targeting therapy is considered an important strategy for cancer treatment.(3-
Carboxypropyl) triphenyl phosphonium (CTPP) is one of the candidate molecules that can …

Mitochondria are recognized as one of the most important targets for new drug design in
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …

Liposome is a conventional drug delivery system which has been widely used in the
pharmacy field. However, its applications are greatly restricted in clinical practice by the …