RNA, DNA, and protein molecules are highly organized within three-dimensional (3D)
structures in the nucleus. Although RNA has been proposed to play a role in nuclear …

Mammalian genomes are organized into three-dimensional DNA structures called A/B
compartments that are associated with transcriptional activity/inactivity. However, whether …

Mammalian genomes encode tens of thousands of noncoding RNAs. Most noncoding
transcripts exhibit nuclear localization and several have been shown to play a role in the …

The importance of three-dimensional chromatin organisation in genome regulation has
never been clearer. But in spite of the enormous technological advances to probe chromatin …

The four-dimensional nucleome (4DN) consortium studies the architecture of the genome
and the nucleus in space and time. We summarize progress by the consortium and highlight …

The human genome consists of more than 2 m of linear DNA, which is packaged into a three-
dimensional structure in the nucleus of each cell. To ensure proper cell-type–specific gene …

RNA structure is intimately connected to each step of gene expression. Recent advances
have enabled transcriptome-wide maps of RNA secondary structure, called 'RNA …

It has long been proposed that nuclear RNAs might play an important role in organizing the
structure of the nucleus. Initial experiments performed more than 30 years ago found that …

Nuclei require a precise three-and four-dimensional organization of DNA to establish cell-
specific gene-expression programs. Underscoring the importance of DNA topology …

Identifying pairwise RNA-RNA interactions is key to understanding how RNAs fold and
interact with other RNAs inside the cell. We present a high-throughput approach …