Novobiocin is a member of the coumermycin family of antibiotics and is a well-established
inhibitor of DNA gyrase. Recent studies have shown that novobiocin binds to a previously …

Recent studies have shown that the DNA gyrase inhibitor, novobiocin, binds to a previously
unrecognized ATP-binding site located at the C-terminus of Hsp90 and induces degradation …

Novobiocin, a known DNA gyrase inhibitor, binds to a nucleotide-binding site located on the
Hsp90 C-terminus and induces degradation of Hsp90-dependent client proteins at∼ 700 …

The 90 kDa heat shock proteins (Hsp90), which are integrally involved in cell signaling,
proliferation, and survival, are ubiquitously expressed in cells. Many proteins in tumor cells …

The coumarin antibiotics are not only potent inhibitors of DNA gyrase but also represent the
most effective C-terminal inhibitors of 90 kDa heat shock proteins (Hsp90) reported thus far …

Development of the DNA gyrase inhibitor, novobiocin, into a selective Hsp90 inhibitor was
accomplished through structural modifications to the amide side chain, coumarin ring, and …

The design, synthesis, and biological evaluation of conformationally constrained
coumermycin A1 analogues are reported. Compounds were evaluated against both breast …

Drugs that inhibit the activity of DNA gyrase fall almost exclusively into two structural classes,
the quinolones and the coumarins. A third class of DNA gyrase inhibitor is defined by the …

Novobiocin is a C-terminal inhibitor of the Hsp90 protein folding machinery, which is
responsible for the conformational maturation of numerous proteins involved in cancer …

We have characterized the interaction of a new class of antibiotics, simocyclinones, with
bacterial DNA gyrase. Even though their structures include an aminocoumarin moiety, a key …