Objective To evaluate the role of immune cells and their effector cytokines in the
pathogenesis and progression of knee osteoarthritis (OA) in matched OA synovial fluid (SF) …

Background Chronic, low-grade inflammation of the synovium (synovitis) is a hallmark of
osteoarthritis (OA), thus understanding of OA immunobiology, mediated by immune …

Background To identify a synovial fluid (SF) biomarker profile characteristic of individuals
with an inflammatory osteoarthritis (OA) endotype. Methods A total of 48 knees (of 25 …

Osteoarthritis (OA) is considered a degenerative joint disorder caused by mechanical wear
to the articular surface. However, while joint injury, obesity, and mutations in collagen …

Objective Monocytes contribute to synovitis and disease pathogenesis in osteoarthritis (OA).
Low-grade inflammation occurs in OA and correlates with disease severity and progression …

Effective treatment of osteoarthritis (OA) remains a huge clinical challenge despite major
research efforts. Different tissues and cell-types within the joint contribute to disease …

Objective To evaluate the ability of the macrophage markers CD163 and CD14 to predict
different osteoarthritis (OA) phenotypes defined by severity of joint inflammation …

Osteoarthritis (OA) is a chronic disability that significantly impairs quality of life. OA is one of
the most prevalent joint pathologies in the world, characterized by joint pain and stiffness …

OBJECTIVE: Although osteoarthritis (OA) is considered a non-inflammatory condition, it is
widely accepted that synovial inflammation is a feature of OA. However, the role of immune …

The aim of this study was to identify inflammatory mediators of potential clinical relevance in
synovial fluid (SF) samples of patients with knee osteoarthritis (OA). Therefore, radiographic …