This thesis is concerned with the development of new techniques for measuring and
modelling lung microstructure with hyperpolarised gas magnetic resonance imaging (MRI) …

Purpose To demonstrate three‐dimensional (3D) multiple b‐value diffusion‐weighted (DW)
MRI of hyperpolarized 3He gas for whole lung morphometry with compressed sensing (CS) …

Purpose Parallel imaging can be used to reduce imaging time and to increase the spatial
coverage in hyperpolarized gas magnetic resonance imaging of the lung. In this proof‐of …

The ability to regionally assess lung function and/or microstructure has both scientific and
diagnostic advantages, and yet the lung is notoriously difficult to image. New techniques and …

Compressed sensing (CS) was implemented to reduce scan time and facilitate acquisition of
3D multiple b-value 3 He diffusion-weighted (DW) MRI data for whole lung morphometry. A …

Hyperpolarized gas pulmonary MRI provides physiologically relevant biomarkers of
obstructive lung disease including emphysema, bronchopulmonary dysplasia, congenital …

Lung morphometry parameters can be derived from multiple b-value hyperpolarized gas
diffusion-weighted (DW)-MRI using the cylinder (CM) and stretched exponential (SEM) …

Although diffusion-based in vivo lung morphometry with hyperpolarized gases MRI is a
powerful tool to study lung diseases, it is usually performed in a 2D mode with only a few …

In this paper we demonstrate that gradient echo MRI with hyperpolarized 3He gas can be
used for simultaneously extracting in vivo information about lung ventilation properties …

Lung morphometry technique with hyperpolarized 3He allows quantification of lung
geometrical parameters such as mean chord length Lm, surface-to-volume ratio S/V and …