The role of embryonic stem cell-expressed RAS (ERAS) in the maintenance of quiescent hepatic stellate cells

S Nakhaei-Rad, H Nakhaeizadeh, S Götze… - Journal of Biological …, 2016 - ASBMB
Hepatic stellate cells (HSCs) were recently identified as liver-resident mesenchymal stem
cells. HSCs are activated after liver injury and involved in pivotal processes, such as liver …

Hepatic stellate cells regulate hepatic progenitor cells differentiation via the TGF‐β1/Jagged1 signaling axis

Y Aimaiti, X Jin, Y Shao, W Wang… - Journal of Cellular …, 2019 - Wiley Online Library
Hepatic stellate cells (HSCs) play an important microenvironmental role in hepatic
progenitor cells (HPCs) differentiation fate. To reveal the specific mechanism of HSCs …

Interaction of hepatic stellate cells with neutrophils and macrophages in the liver following oncogenic kras activation in transgenic zebrafish

Q Yang, C Yan, Z Gong - Scientific Reports, 2018 - nature.com
Activation of hepatic stellate cells (HSC) plays a crucial role in the liver disease progression
from liver fibrosis/cirrhosis to cancer. Here, we found a rapid change of microenvironment …

Fate-mapping evidence that hepatic stellate cells are epithelial progenitors in adult mouse livers

L Yang, Y Jung, A Omenetti, RP Witek, S Choi… - Stem …, 2008 - academic.oup.com
Liver injury activates quiescent hepatic stellate cells (Q-HSC) to proliferative myofibroblasts.
Accumulation of myofibroblastic hepatic stellate cells (MF-HSC) sometimes causes cirrhosis …

Hepatic stellate cells and hepatocarcinogenesis

AE Barry, R Baldeosingh, R Lamm, K Patel… - Frontiers in cell and …, 2020 - frontiersin.org
Hepatic stellate cells (HSCs) are a significant component of the hepatocellular carcinoma
(HCC) tumor microenvironment (TME). Activated HSCs transform into myofibroblast-like …

Phenotypes and ontogeny of senescent hepatic stellate cells in metabolic dysfunction-associated steatohepatitis

CN Yashaswini, T Qin, D Bhattacharya, C Amor… - Journal of …, 2024 - Elsevier
Background & Aims Hepatic stellate cells (HSCs) are the key drivers of fibrosis in metabolic
dysfunction-associated steatohepatitis (MASH), the fastest growing cause of hepatocellular …

[PDF][PDF] The basic helix‐loop‐helix transcription factor, heart and neural crest derivatives expressed transcript 2, marks hepatic stellate cells in zebrafish: Analysis of …

C Yin, KJ Evason, JJ Maher, DYR Stainier - Hepatology, 2012 - Wiley Online Library
Hepatic stellate cells (HSCs) are liver‐specific mesenchymal cells that play vital roles in liver
development and injury. Our knowledge of HSC biology is limited by the paucity of in vivo …

Hepatic stellate cells contribute to liver regeneration through galectins in hepatic stem cell niche

JY Ge, YW Zheng, T Tsuchida, K Furuya… - Stem Cell Research & …, 2020 - Springer
Background As a critical cellular component in the hepatic stem cell niche, hepatic stellate
cells (HSCs) play critical roles in regulating the expansion of hepatic stem cells, liver …

Role of the Ets-1 transcription factor during activation of rat hepatic stellate cells in culture

T Knittel, D Kobold, J Dudas, B Saile… - The American journal of …, 1999 - Elsevier
During liver tissue repair, hepatic stellate cells (HSCs), a pericyte-like nonparenchymal liver
cell population, transform from a quiescent status (resting HSCs. into myofibroblast like cells …

Relationships among stellate cell activation, progenitor cells, and hepatic regeneration

T Roskams - Clinics in liver disease, 2008 - Elsevier
Hepatic stellate cells (HSC) play an important role in liver fibrogenesis. They are also key
players in liver regeneration as part of the stem cell niche of hepatocytes and hepatic …