Long-term excessive dietary phosphate intake increases arterial blood pressure, activates the renin–angiotensin–aldosterone system, and stimulates sympathetic …

N Latic, M Peitzsch, A Zupcic, J Pietzsch, RG Erben - Biomedicines, 2022 - mdpi.com
Increased dietary phosphate intake has been associated with severity of coronary artery
disease, increased carotid intima–media thickness, left ventricular hypertrophy (LVH), and …

High phosphate diet increases arterial blood pressure via a parathyroid hormone mediated increase of renin

M Bozic, S Panizo, MA Sevilla, M Riera… - Journal of …, 2014 - journals.lww.com
Background: There is growing evidence suggesting that phosphate intake is associated with
blood pressure levels. However, data from epidemiological studies show inconsistent …

Hyperphosphatemia and cardiovascular disease

C Zhou, Z Shi, N Ouyang, X Ruan - Frontiers in Cell and …, 2021 - frontiersin.org
Hyperphosphatemia or even serum phosphate levels within the “normal laboratory range”
are highly associated with increased cardiovascular disease risk and mortality in the general …

Effects of dietary phosphate on glucose and lipid metabolism

M Abuduli, H Ohminami, T Otani… - American Journal …, 2016 - journals.physiology.org
Recent epidemiological and animal studies have suggested that excess intake of phosphate
(Pi) is a risk factor for the progression of chronic kidney disease and its cardiovascular …

A chronic high phosphate intake in mice is detrimental for bone health without major renal alterations

M Ugrica, C Bettoni, S Bourgeois… - Nephrology Dialysis …, 2021 - academic.oup.com
Background Phosphate intake has increased in the last decades due to a higher
consumption of processed foods. This higher intake is detrimental for patients with chronic …

Chronic High Phosphate Intake in Mice Affects Macronutrient Utilization and Body Composition

M Ugrica, N Gehring, P Giesbertz… - Molecular Nutrition & …, 2022 - Wiley Online Library
Scope In the last decades, dietary phosphate intake has increased due to a higher
consumption of ultraprocessed food. This higher intake has an impact on body composition …

High phosphate‐induced progressive proximal tubular injury is associated with the activation of Stat3/Kim‐1 signaling pathway and macrophage recruitment

B Richter, T Kapanadze, N Weingärtner… - The FASEB …, 2022 - Wiley Online Library
Dietary phosphate intake in the Western population greatly exceeds the recommended
dietary allowance and is linked to enhanced cardiovascular and all‐cause mortality. It is …

High phosphate impairs arterial endothelial function through AMPK‐related pathways in mouse resistance arteries

W Hu, S Jiang, Y Liao, J Li, F Dong, J Guo… - Acta …, 2021 - Wiley Online Library
Aims In patients with renal disease, high serum phosphate shows a relationship with
cardiovascular risk. We speculate that high phosphate (HP) impairs arterial vasodilation via …

High dietary phosphate intake induces hypertension and augments exercise pressor reflex function in rats

M Mizuno, JH Mitchell, S Crawford… - American Journal …, 2016 - journals.physiology.org
An increasing number of studies have linked high dietary phosphate (Pi) intake to
hypertension. It is well established that the rise in sympathetic nerve activity (SNA) and …

A high phosphate diet lowers blood pressure in spontaneously hypertensive rats.

RJ Bindels, LA Van Den Broek, SJ Hillebrand… - …, 1987 - Am Heart Assoc
Plasma phosphate values are significantly lower in spontaneously hypertensive rats (SHR)
than in normotensive Wistar-Kyoto rats (WKY). In this study, we increased plasma phosphate …