Repair of the endothelial cell barrier after inflammatory injury is essential for tissue fluid
homeostasis and normalizing leukocyte transmigration. However, the mechanisms of …

Vascular smooth muscle cells (VSMCs) can transdifferentiate into macrophage-like cells in
the context of sustained inflammatory injury, which drives vascular hyperplasia and …

Although it is well recognized that haematopoietic stem cells (HSCs) develop from a
specialized population of endothelial cells known as haemogenic endothelium, the …

Fibrosis is a hallmark of chronic disease. Although fibroblasts are involved, it is unclear to
what extent endothelial cells also might contribute. We detected increased expression of the …

Studies have demonstrated the phenotypic heterogeneity of vascular endothelial cells (ECs)
within a vascular bed; however, little is known about how distinct endothelial subpopulations …

After acute kidney injury (AKI), surviving cells within the nephron proliferate and repair. We
identify Sox9 as an acute epithelial stress response in renal regeneration. Translational …

Endothelial to mesenchymal transition (EndMT) is a leading cause of fibrosis and disease,
however its mechanism has yet to be elucidated. The endothelium possesses a profound …

Objective—SOX18, a member of the SOX gene family (SRY-like 3-hydroxy-3-methylglutaryl
box gene), is a transcription factor expressed in the development of blood vessels during …

SOCS3 is the main inhibitor of the JAK/STAT3 pathway. This pathway is activated by
interleukin 6 (IL-6), a major mediator of the cytokine storm during shock. To determine its …

The kidney has a tremendous capacity to regenerate following injury, but factors that govern
this response are still largely unknown. We isolated cells from mouse kidneys with high …