Background The nucleus accumbens is the ventral extent of the striatum, the main input
nucleus of the basal ganglia. Recent hypotheses propose that the accumbens and its …

The nucleus accumbens is part of the neural circuit that controls reward-seeking in response
to reward-predictive cues. Dopamine release in the accumbens is essential for the normal …

Nearly 40 years of research on the function of the nucleus accumbens (NAc) has provided a
wealth of information on its contributions to behavior but has also yielded controversies and …

Substance use disorder (SUD) is characterized, in part by behavior biased toward drug use
and away from natural sources of reward (eg, social interaction, food, sex). The …

In summary, the nucleus accumbens, located at the interface of the limbic projections from
the amygdala, hippocampus, and cingulate cortex, and receiving extrapyramidal fibers from …

It has been suggested that accumbens dopamine (DA) is involved in the process of enabling
organisms to expend energy in various situations, including foraging, maze running, and …

The nucleus accumbens regulates goal-directed behaviors by integrating information from
limbic structures and the prefrontal cortex. Here, we review recent studies in an attempt to …

Limbic forebrain structures and the hypothalamus are essential in the initiation of food-
seeking, escape from predators and other behaviors essential for adaptation and survival …

Anatomical and functional refinements of the meso-limbic dopamine system of the rat are
discussed. Present experiments suggest that dopaminergic neurons localized in the …

Extracellular single unit recordings were obtained from the nucleus accumbens of urethane
anesthetized rats. It was found that electrical stimulation of the basal lateral and basal …