Procalcitonin is not a reliable biomarker of bacterial coinfection in people with coronavirus disease 2019 undergoing microbiological investigation at the time of …

KA Relph, CD Russell, CJ Fairfield… - Open forum …, 2022 - academic.oup.com
Admission procalcitonin measurements and microbiology results were available for 1040
hospitalized adults with coronavirus disease 2019 (from 48 902 included in the International …

Limited utility of procalcitonin in identifying community-associated bacterial infections in patients presenting with coronavirus disease 2019

M May, M Chang, D Dietz, S Shoucri… - Antimicrobial Agents …, 2021 - Am Soc Microbiol
The role of procalcitonin in identifying community-associated bacterial infections among
patients with coronavirus disease 2019 is not yet established. In 2,443 patients of whom 148 …

Elucidating the role of procalcitonin as a biomarker in hospitalized COVID-19 patients

K Cowman, J Rossi, I Gendlina, Y Guo, S Liu… - … and infectious disease, 2022 - Elsevier
Our objectives were to evaluate the role of procalcitonin in identifying bacterial co-infections
in hospitalized COVID-19 patients and quantify antibiotic prescribing during the 2020 …

Negative predictive value of procalcitonin to rule out bacterial respiratory co-infection in critical covid-19 patients

R Carbonell, S Urgelés, M Salgado, A Rodríguez… - Journal of Infection, 2022 - Elsevier
ABSTRACT Background: Procalcitonin (PCT) and C-Reactive Protein (CRP) are useful
biomarkers to differentiate bacterial from viral or fungal infections, although the association …

The dynamics of procalcitonin in COVID-19 patients admitted to Intensive care unit-a multi-centre cohort study in the South West of England, UK.

P Williams, C McWilliams, K Soomro… - Journal of …, 2021 - journalofinfection.com
In this Journal, Seaton and colleagues recently demonstrated the importance and impact of
antimicrobial stewardship during the current pandemic. 1 Severe COVID-19 infections are …

Elevated procalcitonin concentrations in severe Covid-19 may not reflect bacterial co-infection

RS Heer, AKJ Mandal, J Kho… - Annals of clinical …, 2021 - journals.sagepub.com
Background The variability of Covid-19 severity between patients has driven efforts to
identify prognosticating laboratory markers that could aid clinical decision-making …

The use of procalcitonin as an antimicrobial stewardship tool and a predictor of disease severity in coronavirus disease 2019 (COVID-19)

GP Drewett, OC Smibert, NE Holmes… - Infection Control & …, 2022 - cambridge.org
To the Editor—Prior to the coronavirus disease 2019 (COVID-19) pandemic, serum
procalcitonin (PCT)-based antimicrobial stewardship (AMS) algorithms have been shown to …

Baseline procalcitonin as a predictor of bacterial infection and clinical outcomes in COVID-19: A case-control study

NJ Atallah, HM Warren, MB Roberts, RH Elshaboury… - PLoS …, 2022 - journals.plos.org
Purpose Coronavirus disease-2019 (COVID-19) is associated with a wide spectrum of
clinical symptoms including acute respiratory failure. Biomarkers that can predict outcomes …

Routine measurement of serum procalcitonin allows antibiotics to be safely withheld in patients admitted to hospital with SARS-CoV-2 infection

EJ Williams, L Mair, TI de Silva, DJ Green, P House… - medRxiv, 2020 - medrxiv.org
Background It can be a diagnostic challenge to identify COVID-19 patients without bacterial
co-infection in whom antibiotics can be safely stopped. We sought to evaluate the validity of …

Nonutility of procalcitonin for diagnosing bacterial pneumonia in patients with severe COVID-19

AJ Cohen, LR Glick, S Lee, Y Kunitomo… - European Clinical …, 2023 - Taylor & Francis
Background Patients hospitalized with COVID-19 are at significant risk for superimposed
bacterial pneumonia. However, diagnosing superinfection is challenging due to its clinical …