State-of-the-art proteomics-grade mass spectrometers can measure peptide precursors and
their fragments with ppm mass accuracy at sequencing speeds of tens of peptides per …

We describe the use and application of high-field asymmetric waveform ion mobility
spectrometry combined with nanoscale liquid chromatography mass spectrometry (nanoLC …

Although only a few years old, the combination of a linear ion trap with an Orbitrap analyzer
has become one of the standard mass spectrometers to characterize proteins and …

Liquid chromatography (LC) prefractionation is often implemented to increase proteomic
coverage; however, while effective, this approach is laborious, requires considerable …

Over the past decade, developments in high resolution mass spectrometry have enabled the
high throughput analysis of intact proteins from complex proteomes, leading to the …

There is an immediate need for improved methods to systematically and precisely quantify
large sets of peptides in complex biological samples. To date protein quantification in …

We evaluate the quantitative performance of the newly released Asymmetric Track Lossless
(Astral) analyzer. Using data-independent acquisition, the Thermo Scientific Orbitrap Astral …

The depth of proteomic analyses is often limited by the overwhelming proportion of
confounding background ions that compromise the identification and quantification of low …

Shotgun proteomics is a powerful technology for global analysis of proteins and their post-
translational modifications. Here, we investigate the faster sequencing speed of the latest Q …

Advances in proteomics are continually driven by the introduction of new mass spectrometric
instrumentation with improved performances. The recently introduced quadrupole Orbitrap …