[PDF][PDF] Addressing the patient-device use interface: development and laboratory validation of a facemask with anatomically-responsive face models

JP Mitchell, R Morton, D Engelbreth, MW Nagel… - Inhal Mag, 2013 - inhalationmag.com
Many patients, particularly the very young, the elderly and those with co-morbidities affecting
coordination, need to use a facemask rather than a mouthpiece in order to receive inhaled …

Appropriate face models for evaluating drug delivery in the laboratory: the current situation and prospects for future advances

JP Mitchell - Journal of aerosol medicine and pulmonary drug …, 2008 - liebertpub.com
The laboratory evaluation of inhalers with facemasks for patient interface is so complex that
testing without a facemask is generally undertaken, a practice that has been advocated in …

[PDF][PDF] Development of ADAM (Aerosol Delivery to Anatomical Model face) for the evaluation of valved holding chambers (VHCs) with facemask attachment

AK Meyer, MR Limbrick, MW Nagel… - Drug Delivery to the …, 2005 - researchgate.net
The fit of a facemask, when used in conjunction with a VHC for the delivery of medication to
the poorly coordinated patient, has an important influence on the quantity of drug that is …

Breath-by-breath delivered dose comparison from three anti-static valved holding chambers with facemasks under simulated pediatric breathing conditions

W Hsu, D von Hollen, Z Xu, T Bai, K Nikander, R Dalby - 2011 - Eur Respiratory Soc
Facemasks serve as a patient-device interface to facilitate drug delivery from a pressurized
metered dose inhaler (pMDI) with an attached valved holding chamber (VHC), and are …

Development and evaluation of a family of human face and upper airway models for the laboratory testing of orally inhaled products

MW Nagel, JA Suggett, DP Coppolo, JP Mitchell - AAPS PharmSciTech, 2017 - Springer
Many orally inhaled products are supplied with a facemask instead of a mouthpiece,
enabling aerosolized medication to be transferred from the inhaler to the lungs when the …

Medication delivery testing of valved holding chambers (VHCs) with facemask for infant use by means of a model infant face

J Suggett, M Nagel, V Avvakoumova, J Mitchell - 2016 - Eur Respiratory Soc
RATIONALE: This laboratory study used a model taken from a 7-month infant with soft tissue
face modeling and an anatomically correct oro and nasopharynx to explore medication …

Methodology for the In Vitro Evaluation of the Delivery Efficiency from Valved Holding Chambers with Facemasks

Z Xu, W Hsu, D von Hollen, A Viswanath… - Journal of Aerosol …, 2014 - liebertpub.com
Background: In vitro performance studies of valved holding chamber (VHC)-facemask
systems are a cost-effective means of circumventing potentially confounding clinical …

Review of optimal characteristics of face‐masks for valved‐holding chambers (VHCs)

I Amirav, MT Newhouse - Pediatric pulmonology, 2008 - Wiley Online Library
Inhaled drugs are frequently given to infants and young children with a pressurized metered‐
dose inhaler (pMDI) attached to a valved‐holding chamber (VHC) with face mask. In young …

Validation Of A New Model Infant Face with Naso-Pharynx For The Testing Of Valved Holding Chambers (VHCs) With Facemask As Patient Interface

J Mitchell, JB Finlay, MW Nagel, JM Nuttall… - B56. MEASURING …, 2010 - atsjournals.org
METHODS: We report the evaluation of a new simulated model of a 7-month obligate nasal
breathing infant (upper airway based on model# 7 in Storey-Bishoff(2008). 39 (12): 1055 …

[HTML][HTML] More Realistic Face Model Surface Improves Relevance of Pediatric In-Vitro Aerosol Studies

I Amirav, A Halamish, M Gorenberg, H Omar… - PLoS …, 2015 - journals.plos.org
Background Various hard face models are commonly used to evaluate the efficiency of
aerosol face masks. Softer more realistic “face” surface materials, like skin, deform upon …