Aims PCSK9 loss of function genetic variants are associated with lower low-density
lipoprotein cholesterol but also with higher plasma glucose levels and increased risk of Type …

Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays an important role in cholesterol
homeostasis by promoting the degradation of the LDL receptor (LDLR). PCSK9 loss-of …

Proprotein convertase subtilisin/kexin type 9 (PCSK9), a liver-secreted plasma enzyme,
restricts hepatic uptake of low-density lipoprotein (LDL) cholesterol by promoting the …

Background Proprotein convertase subtilisin kexin type 9 (PCSK9) regulates low-density
lipoprotein and very low-density lipoprotein receptor expression in several tissues. Here we …

PCSK9 (Proprotein Convertase Subtilisin Kexin type 9) is a proprotein convertase that plays
a key role in cholesterol homeostasis by decreasing hepatic low-density lipoprotein receptor …

Aims PCSK9 is secreted into the circulation, mainly by the liver, and interacts with low-
density lipoprotein receptor (LDLR) homologous and non-homologous receptors, including …

Clinical trials have unequivocally shown that inhibition of proprotein convertase
subtilisin/kexin type 9 (PCSK9) efficaciously and safely prevents cardiovascular events by …

Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes the
degradation of the LDL receptor (LDLr) in hepatocytes, and its expression in mouse liver has …

Context: PCSK9 is a secreted protein that influences plasma levels of low-density lipoprotein
cholesterol (LDL-C) and susceptibility to coronary heart disease. PCSK9 is present in …

Pro-protein convertase subtilisin/kexin type 9 (PCSK9) is secreted mostly by hepatocytes
and to a lesser extent by the intestine, pancreas, kidney, adipose tissue, and vascular cells …