Iron homeostasis is essential for health; moreover, hepcidin-deficiency results in iron
overload in both hereditary hemochromatosis and iron-loading anemia. Here, we identified …

The iron regulatory hormone hepcidin limits iron fluxes to the bloodstream by promoting
degradation of the iron exporter ferroportin in target cells. Hepcidin insufficiency causes …

Anemia of inflammation (AI) is common in patients with infection, autoimmune diseases,
cancer, and chronic kidney disease. Unless the underlying condition can be reversed …

The liver is the organ for iron storage and regulation; it senses circulating iron
concentrations in the body through the BMP‐SMAD pathway and regulates the iron intake …

Iron deficiency (ID) is relatively common among the elderly population, contributing
substantially to the high prevalence of anemia observed in the last decades of life, which in …

Anemia of chronic disease (ACD) or anemia of inflammation is prevalent in patients with
chronic infection, autoimmune disease, cancer, and chronic kidney disease. ACD is …

Histone deacetylases (HDACs) are epigenetic regulators that play an important role in
determining cell fate and maintaining cellular homeostasis. However, whether and how …

The discovery of hepcidin has triggered a virtual explosion of studies on iron metabolism
and related disorders, the results of which have profoundly changed our view of human …

Iron maldistribution has been implicated in multiple diseases, including the anemia of
inflammation (AI), atherosclerosis, diabetes, and neurodegenerative disorders. Iron …

The maintenance of stable extracellular and intracellular iron concentrations requires the
coordinated regulation of iron transport into plasma. Iron is a fundamental cofactor for …