Signal transducer and activator of transcription 3 (STAT3), a member of the STAT family,
discovered in the cytoplasm of almost all types of mammalian cells, plays a significant role in …

Signal transducer and activator of transcription 3 (STAT3) controls many biological
processes including differentiation, survival, proliferation, and angiogenesis. In normal …

Signal transducer and activator of transcription 3 (STAT3) is a transcriptional factor involved
in almost all cancer hallmark features including tumor proliferation, metastasis …

Drug repurposing is a valuable approach in delivering new cancer therapeutics rapidly into
the clinic. Existing safety and patient tolerability data for drugs already in clinical use …

As a transcription factor, STAT3 protein transduces extracellular signals to the nucleus and
then activates transcription of target genes. STAT3 has been well validated as an attractive …

Excessive activation of signal transducer and activator of transcription 3 (STAT3) signaling is
observed in a subset of many cancers, making activated STAT3 a highly promising potential …

Background: Aberrant activation of the signal transducer and activator of transcription
(STAT) 3 occurs in many human tumors. Moreover, studies utilizing genetic and …

Multiple lines of evidence place STAT3 at a central node in the development, progression,
and maintenance of many human tumors, and STAT3 has been validated as an anti-cancer …

Signal transducer and activator of transcription (STAT) proteins represent novel therapeutic
targets for the treatment of cancer. In particular, STAT‑3 serves critical roles in several …

Signal transducer and activator of transcription 3 (STAT3) is a cytoplasmic transcription
factor that regulates cell proliferation, differentiation, apoptosis, angiogenesis, inflammation …