Pre-mRNA maturation frequently occurs at the same time and place as transcription by RNA
polymerase II. The co-transcriptionality of mRNA processing has permitted the evolution of …

Alternative splicing modulates expression of most human genes. The kinetic model of
cotranscriptional splicing suggests that slow elongation expands and that fast elongation …

RNA synthesis by RNA polymerase II and RNA processing are closely coupled during the
transcription cycle of protein‐coding genes. This coupling affords opportunities for quality …

While studies of alternative pre-mRNA splicing regulation have typically focused on RNA-
binding proteins and their target sequences within nascent message, it is becoming …

Transcription and pre-mRNA splicing are extremely complex multimolecular processes that
involve protein–DNA, protein–RNA, and protein–protein interactions. Splicing occurs in the …

RNA processing events that take place on the transcribed pre-mRNA include capping,
splicing, editing, 3′ processing, and polyadenylation. Most of these processes occur co …

Most eukaryotic protein-coding transcripts contain introns, which vary in number and
position along the transcript body. Intron removal through pre-mRNA splicing is tightly linked …

Alternative splicing has emerged as a key contributor to proteome diversity, highlighting the
importance of understanding its regulation. In recent years it became apparent that splicing …

Alternative precursor messenger RNA (pre-mRNA) splicing plays a pivotal role in the flow of
genetic information from DNA to proteins by expanding the coding capacity of genomes …

Transcription of eukaryotic genes by RNA polymerase II (Pol II) yields RNA precursors
containing introns that must be spliced out and the flanking exons ligated together. Splicing …