The present study investigated the influence of the cigarette smoke extract (CSE) on
mammalian thioredoxin reductase (TrxR) activity. TrxR is a selenoenzyme with a …

Mammalian cytosolic thioredoxin reductase (TrxR1) is an attractive target for developing
cancer chemopreventive agents since its inhibition is associated with a reduced growth of …

Thioredoxin reductase (TrxR) is a selenocysteine-containing flavoprotein that catalyzes the
NADPH-dependent reduction of oxidized thioredoxin and plays a key role in regulating …

Cigarette smoking is one of the main sources of toxic chemical exposure to humans and is
the greatest cause of progression of vascular disease. Crotonaldehyde is one of the major …

Here we described novel interactions of the mammalian selenoprotein thioredoxin
reductase (TrxR) with nitroaromatic environmental pollutants and drugs. We found that TrxR …

The aim of this study was to compare the results obtained from two in vitro cytotoxicity
assays that depend upon different mechanisms/modes of action. The Neutral Red Uptake …

The selenoprotein thioredoxin reductase is a key enzyme in selenium metabolism, reducing
selenium compounds and thereby providing selenide to synthesis of all selenoproteins. We …

Oxidative stress plays a key role in mechlorethamine (methylbis (2-chloroethyl) amine, HN2)
toxicity. The thioredoxin system, consisting of thioredoxin reductase (TrxR), thioredoxin, and …

Black tea is recently reported to have anti-carcinogenic effects through pro-oxidant property,
but the underlying mechanisms remain unclear. Mammalian cytosolic thioredoxin reductase …

The thioredoxin system, composed of thioredoxin reductase (TrxR), thioredoxin (Trx), and
NADPH, exerts a wide range of activities in cellular redox control, antioxidant function, cell …