Sex differences in animal models of traumatic brain injury

TG Rubin, ML Lipton - Journal of experimental neuroscience, 2019 - journals.sagepub.com
Traumatic brain injury (TBI) is highly prevalent and there is currently no adequate treatment.
Understanding the underlying mechanisms governing TBI and recovery remains an elusive …

Sex differences in traumatic brain injury: what we know and what we should know

RP Gupte, WM Brooks, RR Vukas, JD Pierce… - Journal of …, 2019 - liebertpub.com
There is growing recognition of the problem of male bias in neuroscience research,
including in the field of traumatic brain injury (TBI) where fewer women than men are …

Sex-related responses after traumatic brain injury: Considerations for preclinical modeling

CB Späni, DJ Braun, LJ Van Eldik - Frontiers in neuroendocrinology, 2018 - Elsevier
Traumatic brain injury (TBI) has historically been viewed as a primarily male problem, since
men are more likely to experience a TBI because of more frequent participation in activities …

Understanding traumatic brain injury in females: a state-of-the-art summary and future directions

EM Valera, ALC Joseph, K Snedaker… - The Journal of head …, 2021 - journals.lww.com
In this report, we identify existing issues and challenges related to research on traumatic
brain injury (TBI) in females and provide future directions for research. In 2017, the National …

Beyond binary: influence of sex and gender on outcome after traumatic brain injury

KR Giordano, LM Rojas-Valencia… - Journal of …, 2020 - liebertpub.com
Traumatic brain injury (TBI) affects millions of individuals each year and is a leading cause
of death and disability worldwide. TBI is heterogeneous and outcome is influenced by a …

Sex matters: repetitive mild traumatic brain injury in adolescent rats

DK Wright, TJ O'Brien, SR Shultz… - Annals of clinical and …, 2017 - Wiley Online Library
Objective Whether sex differences contribute to the heterogeneity of mild traumatic brain
injury (mTBI) and repeated mTBI (Rm TBI) outcomes in adolescents is unknown. Therefore …

Towards an understanding of sex differences in functional outcome following moderate to severe traumatic brain injury: a systematic review

S Slewa-Younan, S Van Den Berg… - Journal of Neurology …, 2008 - jnnp.bmj.com
Background and aim: A clear understanding of the impact sex differences play in clinical
traumatic brain injury (TBI) outcome remains elusive. Animal research suggests that females …

Sexual dimorphism in the inflammatory response to traumatic brain injury

S Villapol, DJ Loane, MP Burns - Glia, 2017 - Wiley Online Library
The activation of resident microglial cells, alongside the infiltration of peripheral
macrophages, are key neuroinflammatory responses to traumatic brain injury (TBI) that are …

Gender and traumatic brain injury: do the sexes fare differently?

JJ Ratcliff, AI Greenspan, FC Goldstein, AY Stringer… - Brain Injury, 2007 - Taylor & Francis
Objective: To examine the relationship between gender and cognitive recovery 1 year
following traumatic brain injury (TBI). Methods: Patients with blunt TBI were identified from …

Performance of male and female C57BL/6J mice on motor and cognitive tasks commonly used in pre-clinical traumatic brain injury research

LB Tucker, AH Fu, JT McCabe - Journal of neurotrauma, 2016 - liebertpub.com
To date, clinical trials have failed to find an effective therapy for victims of traumatic brain
injury (TBI) who live with motor, cognitive, and psychiatric complaints. Pre-clinical …