Oral mucositis: Current knowledge and future directions

SS Shetty, M Maruthi, V Dhara, JAA de Arruda… - Disease-a-Month, 2022 - Elsevier
Oral mucositis secondary to head and neck chemoradiation displays a complex molecular
pathogenesis involving epithelial and microvascular injury, release of pro-inflammatory …

[HTML][HTML] A hypothesis for the pathogenesis of radiation-induced oral mucositis: when biological challenges exceed physiologic protective mechanisms. Implications for …

ST Sonis - Supportive Care in Cancer, 2021 - Springer
Oral mucositis (OM) remains a significant unmet need for patients being treated with
standard concomitant chemoradiation (CRT) regimens for head and neck cancers (HNC) …

Oral mucositis due to high-dose chemotherapy and/or head and neck radiation therapy

RV Lalla, MT Brennan, SM Gordon, ST Sonis… - JNCI …, 2019 - academic.oup.com
Oral mucositis is a common side-effect associated with conventional cancer therapy and has
also recently been reported in association with newly emerging cancer therapies. It is …

[HTML][HTML] Oral mucositis: the hidden side of cancer therapy

C Pulito, A Cristaudo, CL Porta, S Zapperi… - Journal of experimental …, 2020 - Springer
Inflammation response of epithelial mucosa to chemo-radiotherapy cytotoxic effects leads to
mucositis, a painful side effect of antineoplastic treatments. About 40% of the patients treated …

Emerging pharmacotherapy trends in preventing and managing oral mucositis induced by chemoradiotherapy and targeted agents

M Gobbo, J Joy, H Guedes, MA Shazib… - Expert opinion on …, 2024 - Taylor & Francis
Introduction The introduction of targeted therapy and immunotherapy has tremendously
changed the clinical outcomes and prognosis of cancer patients. Despite innovative …

Chemotherapy-induced and/or radiation therapy-induced oral mucositis-complicating the treatment of cancer

MUR Naidu, GV Ramana, PU Rani, A Suman, P Roy - Neoplasia, 2004 - Elsevier
The term mucositis is coined to describe the adverse effects of radiation and chemotherapy
treatments. Mucositis is one of the most common adverse reactions encountered in radiation …

[HTML][HTML] Confounding factors in the assessment of oral mucositis in head and neck cancer

L Lorini, F Perri, S Vecchio, L Belgioia… - Supportive Care in …, 2022 - Springer
Abstract Treatment of locally advanced head and neck carcinoma not amenable for surgical
resection or resected with high-risk features is usually based on (chemo-) radiation …

Oral mucositis: an update on innate immunity and new interventional targets

C Chen, Q Zhang, W Yu, B Chang… - Journal of Dental …, 2020 - journals.sagepub.com
Oral mucositis (OM), a common debilitating toxicity associated with chemo-and radiation
therapies, is a significant unmet clinical need for head and neck cancer patients. The …

Research advances in oral mucositis

DE Peterson - Current opinion in oncology, 1999 - journals.lww.com
Oral mucositis is a common toxicity of high-dose chemotherapy and upper mantle head and
neck radiation. Published evidence from the past 14 months provides insight into the …

Pathogenesis and amelioration of radiation-induced oral mucositis

CT Lee, TJ Galloway - Current treatment options in oncology, 2022 - Springer
Opinion statement Oral mucositis (OM) causes significant detriment to patient quality of life.
Despite advances in RT, chemotherapy, and surgery for HNC which have led to improved …