SWI/SNF is a multi-subunit chromatin remodeling complex that uses the energy of ATP
hydrolysis to reposition nucleosomes, thereby modulating gene expression. Accumulating …

Cancer genome sequencing efforts have revealed the novel theme that chromatin modifiers
are frequently mutated across a wide spectrum of cancers. Mutations in genes encoding …

The SWI/SNF complexes, initially identified in yeast 20 years ago, are a family of multi-
subunit complexes that use the energy of adenosine triphosphate (ATP) hydrolysis to …

SWI/SNF is a multisubunit chromatin-remodeling complex that performs fundamental roles in
gene regulation, cell lineage specification, and organismal development. Mutations that …

SWI/SNF chromatin remodeling complexes are pleomorphic multisubunit cellular machines
that utilize the energy of ATP hydrolysis to modulate chromatin structure. The complexes …

SWI/SNF chromatin remodelling complexes use the energy of ATP hydrolysis to remodel
nucleosomes and to modulate transcription. Growing evidence indicates that these …

The identification of mutations and deletions in the SMARCB1 locus in chromosome band
22q11. 2 in pediatric rhabdoid tumors provided the first evidence for the involvement of the …

Cancer genome-sequencing studies have revealed a remarkably high prevalence of
mutations in genes encoding subunits of the SWI/SNF chromatin-remodelling complexes …

Subunits of mammalian SWI/SNF (mSWI/SNF or BAF) complexes have recently been
implicated as tumor suppressors in human malignancies. To understand the full extent of …

There is increasing evidence that alterations in chromatin remodeling play a significant role
in human disease. The SWI/SNF chromatin remodeling complex family mobilizes …