[HTML][HTML] Characterization of the biochemical and behavioral effects of cannabidiol: implications for migraine
R Greco, M Francavilla, C Demartini… - The journal of headache …, 2023 - Springer
Cannabidiol (CBD) is the main pharmacologically active phytocannabinoid. CBD exerts an
analgesic effect in several pain models, does not have side effects and has low toxicity. The …
analgesic effect in several pain models, does not have side effects and has low toxicity. The …
Chronic pain and cannabidiol in animal models: behavioral pharmacology and future perspectives
GK Silva-Cardoso, CRA Leite-Panissi - Cannabis and Cannabinoid …, 2023 - liebertpub.com
The incidence of chronic pain is around 8% in the general population, and its impact on
quality of life, mood, and sleep exceeds the burden of its causal pathology. Chronic pain is a …
quality of life, mood, and sleep exceeds the burden of its causal pathology. Chronic pain is a …
[HTML][HTML] Cannabidiol for pain treatment: focus on pharmacology and mechanism of action
J Mlost, M Bryk, K Starowicz - International journal of molecular sciences, 2020 - mdpi.com
Cannabis has a long history of medical use. Although there are many cannabinoids present
in cannabis, Δ9tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) are the two …
in cannabis, Δ9tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) are the two …
A placebo‐controlled investigation of the analgesic effects, abuse liability, safety and tolerability of a range of oral cannabidiol doses in healthy humans
Aims Preclinical studies demonstrate that cannabidiol (CBD) elicits an antinociceptive
response in animal models of neuropathic pain; in humans, limited data are available to …
response in animal models of neuropathic pain; in humans, limited data are available to …
The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain
B Costa, AE Trovato, F Comelli, G Giagnoni… - European journal of …, 2007 - Elsevier
Cannabidiol, the major psycho-inactive component of cannabis, has substantial anti-
inflammatory and immunomodulatory effects. This study investigated its therapeutic potential …
inflammatory and immunomodulatory effects. This study investigated its therapeutic potential …
[HTML][HTML] Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain
Clinical studies indicate that cannabidiol (CBD), the primary nonaddictive component of
cannabis that interacts with the serotonin (5-HT) 1A receptor, may possess analgesic and …
cannabis that interacts with the serotonin (5-HT) 1A receptor, may possess analgesic and …
Pain response to cannabidiol in induced acute nociceptive pain, allodynia, and hyperalgesia by using a model mimicking acute pain in healthy adults in a randomized …
T Schneider, L Zurbriggen, M Dieterle, E Mauermann… - Pain, 2022 - journals.lww.com
Preclinical studies have demonstrated the analgesic potential of cannabidiol (CBD). Those
suggesting an effect on pain-processing receptors have brought CBD back into focus. This …
suggesting an effect on pain-processing receptors have brought CBD back into focus. This …
[HTML][HTML] The acute effects of cannabidiol on emotional processing and anxiety: a neurocognitive imaging study
Rationale There is growing interest in the therapeutic potential of cannabidiol (CBD) across
a range of psychiatric disorders. CBD has been found to reduce anxiety during …
a range of psychiatric disorders. CBD has been found to reduce anxiety during …
Evaluating the antinociceptive efficacy of cannabidiol alone or in combination with morphine using the formalin test in male and female mice
DE Sepulveda, DP Morris… - Cannabis and …, 2022 - liebertpub.com
Introduction: Phytocannabinoids have emerged as a potential alternative treatment option
for individuals experiencing persistent pain. However, evidence-based research regarding …
for individuals experiencing persistent pain. However, evidence-based research regarding …
Cannabidiol effectively reverses mechanical and thermal allodynia, hyperalgesia, and anxious behaviors in a neuropathic pain model: Possible role of CB1 and …
The incidence of chronic pain is high in the general population and it is closely related to
anxiety disorders, which promote negative effects on the quality of life. The cannabinoid …
anxiety disorders, which promote negative effects on the quality of life. The cannabinoid …