Recognition of sequences within duplex DNA is a general strategy for probing DNA function
and for disrupting gene expression. Peptide nucleic acids (PNAs) and conjugates between …

The ability of DNA oligonucleotides, neutral peptide nucleic acids (PNAs), and
oligonucleotide conjugates to hybridize to inverted repeat sequences within supercoiled …

Oligonucleotide analogues that have enhanced binding to a complementary sequence are
of potential biologicalinterest. Dimer1 and oligonucleotide2 analogues bearing a moiety …

Peptide nucleic acid (PNA) probes have been synthesized and targeted to quadruplex DNA.
UV− vis and CD spectroscopy reveal that the quadruplex structure of the thrombin binding …

Efficient and selective recognition of DNA by proteins is due to sequence-specific
interactions with a target site and nonselective electrostatic interactions that promote the …

Product inhibition has provided the limiting barrier to efficient template‐directed ligation and
polymerization reactions. Here we review the attempts to circumvent this limitation and …

DNA helix invasion by P-loop forming peptide nucleic acids (PNAs) is extremely sensitive to
increased ionic strength as this stabilizes the DNA duplex. To address this, the DNA …

The use of oligodeoxynucleotides (ODNs) to control gene expression at the DNA level is
hindered by sequence recognition strategies. Triplex formation by Hoogsteen hydrogen …

Peptide nucleic acid oligomers (PNAs) have a remarkable ability to invade duplex DNA at
polypurine–polypyrimidine target sequences. Applications for PNAs in medicine and …

Figure 1.(a)(iop) Schematic demonstrating a possible mode of annealing an oligonucleotide-
peptide conjugate to duplex DNA.(b)(middle) Effect of annealing time on DNA sequencing …