Semaphorins are secreted, transmembrane, and GPI-linked proteins, defined by cysteine-
rich semaphorin protein domains, that have important roles in a variety of tissues. Humans …

Semaphorins are extracellular signaling proteins that are essential for the development and
maintenance of many organs and tissues. The more than 20-member semaphorin protein …

The semaphorins are the products of a large family of genes currently containing more than
30 members. These genes are divided into eight classes of which classes 1, 2 and 8 contain …

Neuronal connections are made during embryonic development with astonishing precision
to ultimately form the physical basis for the central nervous system's main capacity …

Cell-cell signalling of semaphorin ligands through interaction with plexin receptors is
important for the homeostasis and morphogenesis of many tissues and is widely studied for …

Semaphorins were discovered 11 years ago as molecular cues for axon guidance that are
conserved from invertebrates to humans. More than 20 semaphorin genes have been …

Cell-cell communication is pivotal to guide embryo development, as well as to maintain adult
tissues homeostasis and control immune response. Among extracellular factors responsible …

The semaphorins were initially described as axon guidance factors, but have recently been
implicated in a variety of physiological and developmental functions, including regulation of …

Semaphorins are the products of a large gene family containing 28 genes of which 21 are
found in vertebrates. Class-3 semaphorins constitute a subfamily of seven vertebrate …

The semaphorin family is a large group of proteins controlling cell migration and axonal
growth cone guidance. These proteins are bi-functional signals capable of growth promotion …