[HTML][HTML] Tacrolimus-resistant SARS-CoV-2-specific T cell products to prevent and treat severe COVID-19 in immunosuppressed patients

L Peter, DJ Wendering, S Schlickeiser… - … Therapy-Methods & …, 2022 - cell.com
Solid organ transplant (SOT) recipients receive therapeutic immunosuppression that
compromises their immune response to infections and vaccines. For this reason, SOT …

Identification and characterization of T-cell receptors with therapeutic potential showing conserved specificity against all SARS-CoV 2 strains

H Reimann, C Moosmann, K Schober, V Lang… - Immunobiology, 2023 - Elsevier
Introduction Treatment of severe COVID-19 disease can be challenging in
immunocompromized patients due to newly emerging virus variants of concern (VOC) …

[HTML][HTML] Effective virus-specific T-cell therapy for high-risk SARS-CoV-2 infections in hematopoietic stem cell transplant recipients: initial case studies and literature …

L Gopcsa, M Réti, H Andrikovics, I Bobek, G Bekő… - GeroScience, 2024 - Springer
The COVID-19 pandemic has exacerbated mortality rates among immunocompromised
patients, accentuating the need for novel, targeted therapies. Transplant recipients, with their …

[HTML][HTML] The immunology of SARS-CoV-2 infection and vaccines in solid organ transplant recipients

D Dęborska-Materkowska, D Kamińska - Viruses, 2021 - mdpi.com
Since its outbreak in December 2019, the coronavirus disease 2019 (COVID-19) pandemic,
caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), led to an …

[HTML][HTML] Transcriptomic analysis reveals optimal cytokine combinations for SARS-CoV-2-specific T cell therapy products

J Durkee-Shock, CA Lazarski… - … Therapy Methods & …, 2022 - cell.com
Adoptive T cell immunotherapy has been used to restore immunity against multiple viral
targets in immunocompromised patients after bone-marrow transplantation and has been …

[HTML][HTML] Functional SARS-CoV-2-specific T cells of donor origin in allogeneic stem cell transplant recipients of a T-cell-replete infusion: A prospective observational …

C La Rosa, F Chiuppesi, Y Park, Q Zhou… - Frontiers in …, 2023 - frontiersin.org
In the current post-pandemic era, recipients of an allogeneic hematopoietic stem cell
transplant (HCT) deserve special attention. In these vulnerable patients, vaccine …

Engineering immunosuppressive drug-resistant armored (IDRA) SARS-CoV-2 T cells for cell therapy

Q Chen, A Chia, SK Hang, A Lim, WK Koh… - Cellular & molecular …, 2023 - nature.com
Solid organ transplant (SOT) recipients receive immunosuppressive drugs (ISDs) and are
susceptible to developing severe COVID-19. Here, we analyze the Spike-specific T-cell …

The magnitude and functionality of SARS-CoV-2 reactive cellular and humoral immunity in transplant population is similar to the general population despite …

CJ Thieme, M Anft, K Paniskaki… - …, 2021 - journals.lww.com
Background. The ability of transplant (Tx) patients to generate a protective antiviral response
under immunosuppression is pivotal in COVID-19 infection. However, analysis of immunity …

[HTML][HTML] A review of treatment and prevention of coronavirus disease 2019 among solid organ transplant recipients

DJ Buehrle, RR Sutton, EL McCann, AE Lucas - Viruses, 2021 - mdpi.com
Therapeutic management of solid organ transplant (SOT) recipients infected with severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease …

[HTML][HTML] SARS-CoV-2 vaccination in solid-organ transplant recipients

M Peghin, E Graziano, PA Grossi - Vaccines, 2022 - mdpi.com
The coronavirus disease 2019 (COVID-19) pandemic has posed significant global
challenges for solid organ transplant (SOT) recipients. Mortality rates of COVID-19 in this …