Angiopoietin 2 and cardiovascular disease in dialysis and kidney transplantation

S David, P Kümpers, J Hellpap, R Horn, H Leitolf… - American Journal of …, 2009 - Elsevier
BACKGROUND: Accelerated atherosclerosis in patients with chronic kidney disease (CKD)
is still incompletely understood. Angiopoietin 1 (Ang-1) and Ang-2 are 55-kDa antagonistic …

Circulating angiopoietin-2 levels increase with progress of chronic kidney disease

S David, P Kümpers, A Lukasz, D Fliser… - Nephrology Dialysis …, 2010 - academic.oup.com
Abstract Background. Angiopoietin-2 (Ang-2) is an antagonistic ligand of the endothelial-
specific Tie2 receptor. Patients on dialysis have markedly elevated Ang-2 levels, and those …

Angiopoietin-2 levels predict mortality in CKD patients

S David, SG John, HJ Jefferies… - Nephrology Dialysis …, 2012 - academic.oup.com
Background. The pathophysiology of aggravated atherosclerosis in chronic kidney disease
(CKD) is still incompletely understood. However, there is an increasing focus on non …

High plasma angiopoietin-2 levels predict the need to initiate dialysis within two years in patients with chronic kidney disease

A Szymczak, M Kusztal, T Gołębiowski… - International Journal of …, 2023 - mdpi.com
Volume status, congestion, endothelial activation, and injury all play roles in glomerular
filtration rate (GFR) decline. In this study, we aimed to determine whether the plasma …

Association of angiopoietin-2 with renal outcome in chronic kidney disease

YC Tsai, YW Chiu, JC Tsai, HT Kuo, SC Lee, CC Hung… - PloS one, 2014 - journals.plos.org
Background The pathophysiological mechanisms of renal function progression in chronic
kidney disease (CKD) have still not been completely explored. In addition to well-known …

Angiopoietin-2 as a prognostic biomarker of major adverse cardiovascular events and all-cause mortality in chronic kidney disease

YC Tsai, CS Lee, YW Chiu, HT Kuo, SC Lee… - PloS one, 2015 - journals.plos.org
Background Chronic kidney disease (CKD) patients have higher prevalence of major
adverse cardiovascular events (MACE) and all-cause mortality. Endothelial damage and …

Angiopoietin-2, Angiopoietin-1 and subclinical cardiovascular disease in Chronic Kidney Disease

YC Tsai, CS Lee, YW Chiu, HT Kuo, SC Lee… - Scientific reports, 2016 - nature.com
Angiopoietins (Angpt) and vascular endothelial growth factor (VEGF) have been associated
with cardiovascular disease. The study enrolled 270 pre-dialysis stage 3–5 CKD patients to …

Angiopoietin-2 is associated with albuminuria and microinflammation in chronic kidney disease

FC Chang, TS Lai, CK Chiang, YM Chen, MS Wu… - PloS one, 2013 - journals.plos.org
Although cardiovascular disease (CVD) is the leading cause of mortality in patients with
chronic kidney disease (CKD), the pathophysiology is not thoroughly understood. Given that …

Circulating angiopoietin-2 in essential hypertension: relation to atherosclerosis, vascular inflammation, and treatment with olmesartan/pravastatin

S David, P Kümpers, A Lukasz, JT Kielstein… - Journal of …, 2009 - journals.lww.com
Background Endothelial activation has emerged as an early event in the pathogenesis of
cardiovascular disease. Angiopoietin-2 (Ang-2) has been identified as a nonredundant …

Circulating angiopoietin-2 is a marker for early cardiovascular disease in children on chronic dialysis

RC Shroff, KL Price, M Kolatsi-Joannou, AF Todd… - PloS one, 2013 - journals.plos.org
Cardiovascular disease (CVD) is increasingly recognised as a complication of childhood
chronic kidney disease (CKD) even in the absence of diabetes and hypertension. We …