The emergence of new fungal pathogens makes the development of new antifungal drugs a
medical imperative that in recent years motivates the talents of numerous investigators …

Promising new compounds have recently been identified in an effort to supplement the
relatively sparse portfolio of antifungal drugs. Many of these compounds have defined …

With the increasing morbidity and mortality of invasive fungal infections and the emergence
of severe antifungal drug resistance, new drug targets and novel antifungal agents are …

Fungi are one of the most neglected pathogens apparent from the fact that the Amphotericin
B, a polyene antibiotic, discovered way back in 1956 is still used as a'gold standard'for …

Due to their eukaryotic heritage, the differences between a fungal pathogen's molecular
makeup and its human host are small. Therefore, the discovery and subsequent …

In the recent past, prevalence of life threatening fungal diseases have increased rapidly in
immune-compromised cases such as acquired immunodeficiency syndrome (AIDS), cancer …

Recent investigations have yielded both profound insights into the mechanisms required by
pathogenic fungi for virulence within the human host, as well as novel potential targets for …

Fungal infections have aroused much interest over the last years because of their
involvement in several human diseases. Immunocompromission due to transplant-related …

Highlights•Natural products play a crucial role in antifungal drug discovery.•Natural products
represent many first-in-class antifungal agents in clinical trials with new modes of …

The utility of clinically available antifungals is limited by their narrow spectrum of activity,
high toxicity, and emerging resistance. Antifungal drug discovery has always been a …