Closing the gap on drug-induced liver injury
M Maurel, J Rosenbaum - Hepatology, 2012 - journals.lww.com
Drug-induced liver injury (DILI) limits the development and application of many therapeutic
compounds and presents major challenges to the pharmaceutical industry and clinical …
compounds and presents major challenges to the pharmaceutical industry and clinical …
Gap junction inhibition prevents drug-induced liver toxicity and fulminant hepatic failure
Drug-induced liver injury (DILI) limits the development and application of many therapeutic
compounds and presents major challenges to the pharmaceutical industry and clinical …
compounds and presents major challenges to the pharmaceutical industry and clinical …
[HTML][HTML] Involvement of connexin43 in acetaminophen-induced liver injury
M Maes, MR McGill, TC da Silva, C Abels… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Background and aims Being goalkeepers of liver homeostasis, gap junctions are also
involved in hepatotoxicity. However, their role in this process is ambiguous, as gap junctions …
involved in hepatotoxicity. However, their role in this process is ambiguous, as gap junctions …
Gap junction dysfunction reduces acetaminophen hepatotoxicity with impact on apoptotic signaling and connexin 43 protein induction in rat
A Naiki-Ito, M Asamoto, T Naiki, K Ogawa… - Toxicologic …, 2010 - journals.sagepub.com
Acetaminophen (APAP) is a widely used antipyretic and analgesic agent. However,
overdosing and sometimes even a recommended dose can lead to serious and conceivably …
overdosing and sometimes even a recommended dose can lead to serious and conceivably …
Connexin hemichannel inhibition reduces acetaminophen-induced liver injury in mice
M Maes, SC Yanguas, J Willebrords, JL Weemhoff… - Toxicology letters, 2017 - Elsevier
Historically, connexin hemichannels have been considered as structural precursors of gap
junctions. However, accumulating evidence points to independent roles for connexin …
junctions. However, accumulating evidence points to independent roles for connexin …
Connexin32: a mediator of acetaminophen-induced liver injury?
M Maes, MR McGill, TC Da Silva… - Toxicology …, 2016 - Taylor & Francis
Connexin32 is the building block of hepatocellular gap junctions, which control direct
intercellular communication and thereby act as goalkeepers of liver homeostasis. This study …
intercellular communication and thereby act as goalkeepers of liver homeostasis. This study …
The gap junction inhibitor 2-aminoethoxy-diphenyl-borate protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes and c-jun N-terminal …
Acetaminophen (APAP) hepatotoxicity is the leading cause of acute liver failure in the US.
Although many aspects of the mechanism are known, recent publications suggest that gap …
Although many aspects of the mechanism are known, recent publications suggest that gap …
Hepatic Gap Junction Inhibition Limits Liver Injury and Inflammation in Non-alcoholic Steatohepatitis (NASH): 50
Suraj J. Patel1, 3, Jay Luther2, Kevin R. King1, Stefan Bohr1, 3, John Scichilone1, 3, John
Garber2, Lee F. Peng2, Raymond T. Chung2, Martin L. Yarmush1, 3; 1Surgery …
Garber2, Lee F. Peng2, Raymond T. Chung2, Martin L. Yarmush1, 3; 1Surgery …
Connexin 32 deficiency protects the liver against ischemia/reperfusion injury
S Wu, W Yao, C Chen, H Chen, F Huang, Y Liu… - European Journal of …, 2020 - Elsevier
Hepatic ischemia/reperfusion (I/R) injury is a common complication in the clinical setting.
Our previous study has shown that connexin 32 (Cx32) plays a major role in renal I/R injury; …
Our previous study has shown that connexin 32 (Cx32) plays a major role in renal I/R injury; …
[HTML][HTML] Role of connexin 32 in acetaminophen toxicity in a knockout mice model
I Igarashi, T Maejima, K Kai, S Arakawa… - Experimental and …, 2014 - Elsevier
Gap junctional intercellular communication (GJIC), by which glutathione (GSH) and
inorganic ions are transmitted to neighboring cells, is recognized as being largely involved …
inorganic ions are transmitted to neighboring cells, is recognized as being largely involved …