Naphthoquinones are compounds present in several families of higher plants. Their
molecular structures confer redox properties, and they are involved in multiple biological …

Derivatives of natural quinones with biological activities, such as lapachol, α-and β-
lapachones, have been synthesized and their trypanocidal activity evaluated in vitro in …

Chagas disease is one of the most important endemic diseases in Latin America, caused by
Trypanosoma cruzi. The drugs used for the treatment of this disease, nifurtimox and …

Despite ongoing efforts, the current treatment for Chagas disease is still unsatisfactory,
mainly because of the severe side effects and variable efficacy of the available …

Chagas disease is caused by the hemoflagellate protozoa Trypanosoma cruzi and is one of
the most important neglected tropical diseases, especially in Latin American countries …

Four new naphthofuranquinones, obtained from 2-hydroxy-3-allyl-naphthoquinone (1) and
nor-lapachol (2), have their structures established by physical and X-ray analysis and their …

Over the past decades, a number of 1, 4‐naphthoquinones have been isolated from natural
resources and several of naphthoquinone derivatives with diverse structural motif have been …

β-Lapachone and structurally related lipophilic o-naphthoquinones, namely, CG 8-935, CG
9-442, CG 10-248 and mansonones A, C, E, and F, were investigated for redox cycling …

Naphthoquinones isolated from the wood of trees of the families Bignoniaceae and
Verbenaceae have been subjected to an interdisciplinary study since the seventies, when …

An intensive effort has been directed toward finding alternative drugs for treatment of
Chagas' disease, caused by Trypanosoma cruzi, and prophylaxis of blood in endemic areas …