Environmental cues associated with the previously abused drug elicit craving and relapse to
drug use in humans. Several reinstatement paradigms are used in animals to examine the …

Previous studies employed a second-order schedule paradigm maintained by cocaine
reinforcement to show that BP897, a dopamine D 3 partial agonist, selectively modulated …

Rationale. Dopamine D1-receptor antagonists and agonists both attenuate cocaine-seeking
behavior (ie, operant responding in the absence of cocaine reinforcement) elicited by a …

Animal models of relapse to drug seeking have focused primarily on relapse induced by
exposure to drugs, drug-associated cues or contexts, and foot-shock stress. However …

Dopamine (DA) D3 receptors have been suggested to play a role in mechanisms underlying
the ability of drug-associated cues to induce drug-seeking behaviour. The present study …

The dopamine D3 receptor is preferentially localized to the mesocorticolimbic dopaminergic
system and has been hypothesized to play a role in cocaine addiction. To study the …

Rationale Dopamine D 1 receptor agonists and antagonists attenuate reinstatement of
cocaine seeking in a non-human primate model of relapse. The mechanisms by which these …

We have previously reported that selective dopamine (DA) D3 receptor antagonists are
effective in a number of animal models of drug addiction, but not in intravenous drug self …

Dopaminergic mechanisms are thought to be critical in mediating relapse to cocaine-
seeking behavior. This study examined the different roles of D1-and D2-like receptor …

Accumulating evidence indicates that dopamine (DA) D 3 receptor antagonists appear
highly promising in attenuating cocaine reward and relapse in preclinical models of …