Hyperglycemia-driven neuroinflammation compromises BBB leading to memory loss in both diabetes mellitus (DM) type 1 and type 2 mouse models
S Rom, V Zuluaga-Ramirez, S Gajghate, A Seliga… - Molecular …, 2019 - Springer
End organ injury in diabetes mellitus (DM) is driven by microvascular compromise (including
diabetic retinopathy and nephropathy). Cognitive impairment is a well-known complication …
diabetic retinopathy and nephropathy). Cognitive impairment is a well-known complication …
Blood-brain barrier dysfunction precedes cognitive decline and neurodegeneration in diabetic insulin resistant mouse model: an implication for causal link
Diabetic insulin resistance and pro-diabetic diet are reported to increase dementia risk
through unknown mechanisms. Emerging evidence suggests that the integrity of blood-brain …
through unknown mechanisms. Emerging evidence suggests that the integrity of blood-brain …
Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Aβ deposition in an Alzheimer mouse model with diabetes
S Takeda, N Sato, K Uchio-Yamada… - Proceedings of the …, 2010 - National Acad Sciences
Recent epidemiological studies suggest that diabetes mellitus is a strong risk factor for
Alzheimer disease. However, the underlying mechanisms remain largely unknown. In this …
Alzheimer disease. However, the underlying mechanisms remain largely unknown. In this …
Hyperglycemia and advanced glycation end products disrupt BBB and promote occludin and claudin-5 protein secretion on extracellular microvesicles
S Rom, NA Heldt, S Gajghate, A Seliga… - Scientific reports, 2020 - nature.com
Cognitive impairment is a well-known complication of diabetes mellitus (DM). Microvascular
compromise was described one DM complication. Recently we showed blood brain barrier …
compromise was described one DM complication. Recently we showed blood brain barrier …
Blood-brain barrier disruption induced cognitive impairment is associated with increase of inflammatory cytokine
Patients with diabetes suffer the higher risk of dementia and the underlying pathological
mechanism of cognitive dysfunction in diabetes is not fully understood. In this study, we …
mechanism of cognitive dysfunction in diabetes is not fully understood. In this study, we …
Blood brain barrier injury in diabetes: unrecognized effects on brain and cognition
M Bogush, NA Heldt, Y Persidsky - Journal of Neuroimmune …, 2017 - Springer
Diabetes mellitus (DM) is a disorder due to the inability properly to metabolize glucose
associated with dysregulation of metabolic pathways of lipids and proteins resulting in …
associated with dysregulation of metabolic pathways of lipids and proteins resulting in …
Vascular pathology and blood‐brain barrier disruption in cognitive and psychiatric complications of type 2 diabetes mellitus
Y Serlin, J Levy, H Shalev - Cardiovascular psychiatry and …, 2011 - Wiley Online Library
Vascular pathology is recognized as a principle insult in type 2 diabetes mellitus (T2DM). Co‐
morbidities such as structural brain abnormalities, cognitive, learning and memory deficits …
morbidities such as structural brain abnormalities, cognitive, learning and memory deficits …
Exacerbated brain damage, edema and inflammation in type‐2 diabetic mice subjected to focal ischemia
K Tureyen, K Bowen, J Liang… - Journal of …, 2011 - Wiley Online Library
J. Neurochem.(2011) 116, 499–507. Abstract One of the limiting factors in stroke therapeutic
development is the use of animal models that do not well represent the underlying medical …
development is the use of animal models that do not well represent the underlying medical …
Cerebrovascular complications of diabetes: focus on cognitive dysfunction
The incidence of diabetes has more than doubled in the United States in the last 30 years
and the global disease rate is projected to double by 2030. Cognitive impairment has been …
and the global disease rate is projected to double by 2030. Cognitive impairment has been …
High-fat diet-induced diabetes couples to Alzheimer's disease through inflammation-activated C/EBPβ/AEP pathway
Diabetes is a risk factor for Alzheimer's disease (AD), which is also called type 3 diabetes
with insulin reduction and insulin resistance in AD patient brains. However, the molecular …
with insulin reduction and insulin resistance in AD patient brains. However, the molecular …