In an attempt to develop potent anticancer agents targeting Akt, new thiazole derivatives (1–
10) were synthesized and investigated for their cytotoxic effects on A549 human lung …

A series of pyrazole-thiophene derivatives exhibiting good Akt inhibitory activities were
obtained on the basis of conformational restriction strategy, leading to the discovery of …

A new series of 2-substituted thiazole carboxamides were identified as potent pan inhibitors
against all three isoforms of Akt (Akt1, Akt2 and Akt3) by systematic optimization of weak …

The AKT isoforms are a group of key kinases that play a critical role in tumorigenesis. These
enzymes are overexpressed in different types of cancers, such as breast, colon, prostate …

Akt2 is considered as a potential target for cancer therapy. In order to find novel Akt2
inhibitors which have different scaffolds, structure-based pharmacophore model and 3D …

In the current work, new 1, 3, 4-oxadiazole derivatives were synthesized and investigated for
their cytotoxic effects on A549 human lung adenocarcinoma, C6 rat glioma and NIH/3T3 …

A series of 2-aminothiadiazole of inhibitors of AKT1 is described. SAR relationships are
discussed, along with selectivity for protein kinase A (PKA) and cyclin-dependent kinase 2 …

A series of 5-arylamino-6-chloro-1H-indazole-4, 7-diones were synthesized and evaluated
for their inhibitory activity on protein kinase B/Akt. The compounds exhibited a potent Akt1 …

Despite great progress, the current cancer treatments often have obvious toxicity and side
effects. and a poor prognosis (some patients). One of the reasons for the poor prognosis is …

In an attempt to identify potent antitumor agents for the fight against non‐small cell lung
cancer, new thiazolyl hydrazones (2a–n) were synthesized and examined for their in vitro …