Oxysophocarpine suppresses hepatocellular carcinoma growth and sensitizes the therapeutic blockade of anti‐Lag‐3 via reducing FGL1 expression

J Wang, W Wei, Q Tang, L Lu, Z Luo, W Li… - Cancer …, 2020 - Wiley Online Library
Hepatocellular carcinoma (HCC) is an aggressive malignancy with limited effective
treatments and ranks as the second most lethal tumor. Immunotherapy has brought great …

[HTML][HTML] Paeoniflorin inhibits hepatocellular carcinoma growth by reducing PD-L1 expression

M Gao, D Zhang, C Jiang, Q Jin, J Zhang - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Abnormal expression of programmed death-ligand 1 (PD-L1) on cancer cells contributes to
immune escape in hepatocellular carcinoma (HCC). Paeoniflorin has been shown to inhibit …

Trilobolide‐6‐O‐isobutyrate suppresses hepatocellular carcinoma tumorigenesis through inhibition of IL‐6/STAT3 signaling pathway

XQ Zhou, XM Mao, R Fan, SY Li, J Shang… - Phytotherapy …, 2021 - Wiley Online Library
Currently available therapies for hepatocellular carcinoma (HCC), with a high morbidity and
high mortality, are only marginally effective and with sharp adverse side effects, which …

Falcarindiol Enhances Cisplatin Chemosensitivity of Hepatocellular Carcinoma via Down-Regulating the STAT3-Modulated PTTG1 Pathway

H Hong, Z Jin, T Qian, X Xu, X Zhu, Q Fei… - Frontiers in …, 2021 - frontiersin.org
Hepatocellular carcinoma (HCC) is the most frequent primary liver malignancy globally and
the third leading cause of cancer-related death. Chemotherapy is one of the main methods …

[HTML][HTML] Osthole inhibits pancreatic cancer progression by directly exerting negative effects on cancer cells and attenuating tumor-infiltrating M2 macrophages

B Wang, X Zheng, J Liu, Z Zhang, C Qiu, L Yang… - Journal of …, 2018 - Elsevier
Pancreatic cancer has remained a major cause of cancer-related deaths. A hallmark of
pancreatic cancer is extensive stromal reactions, resulting in a unique tumor …

Effect and mechanism of sophoridine to suppress hepatocellular carcinoma in vitro and vivo

BC Wang, J Xu, HY Wang, SW Chang, N Liu - Biomedicine & …, 2017 - Elsevier
Aim The aim of this study is to explain effect and mechanism of Sophoridine to suppress
Hepatocellular carcinoma in vitro and vivo. Methods In vitro experiment, the HepG2 cells …

[HTML][HTML] Growth-suppressive activity of raloxifene on liver cancer cells by targeting IL-6/GP130 signaling

Y Wang, H Ma, C Zhao, T Liu, D Yan, D Jou, H Li… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Background Interleukin-6 (IL-6) is a multifunctional cytokine, which is involved in the
regulation of differentiation and growth of certain types of tumor cells. Constitutive activation …

[HTML][HTML] Plumbagin, a natural naphthoquinone, inhibits the growth of esophageal squamous cell carcinoma cells through inactivation of STAT3

Y Cao, X Yin, Y Jia, B Liu, S Wu… - … Journal of Molecular …, 2018 - spandidos-publications.com
Although plumbagin, a natural naphthoquinone, has exhibited antiproliferative activity in
numerous types of cancer, its anticancer potential in esophageal squamous cell carcinoma …

Exploring the mechanism of flaccidoxide-13-acetate in suppressing cell metastasis of hepatocellular carcinoma

YJ Wu, WC Wei, GF Dai, JH Su, YH Tseng, TC Tsai - Marine drugs, 2020 - mdpi.com
Hepatocellular carcinoma (HCC) is the most common liver or hepatic cancer, accounting for
80% of all cases. The majority of this cancer mortality is due to metastases, rather than …

Combination of wogonin and artesunate exhibits synergistic anti-hepatocellular carcinoma effect by increasing DNA-damage-inducible alpha, tumor necrosis factor α …

M Chen, HL Wu, TS Wong, B Chen, RH Gong… - Frontiers in …, 2021 - frontiersin.org
Hepatocellular carcinoma (HCC) is difficult to treat, and is the second leading cause of
cancer-related death worldwide. This study aimed to examine whether combination of …