Chimeric antigen receptor (CAR) Treg: a promising approach to inducing immunological tolerance
Q Zhang, W Lu, CL Liang, Y Chen, H Liu… - Frontiers in …, 2018 - frontiersin.org
Cellular therapies with polyclonal regulatory T-cells (Tregs) in transplantation and
autoimmune diseases have been carried out in both animal models and clinical trials …
autoimmune diseases have been carried out in both animal models and clinical trials …
CAR-T regulatory (CAR-Treg) cells: engineering and applications
M Arjomandnejad, AL Kopec, AM Keeler - Biomedicines, 2022 - mdpi.com
Regulatory T cells are critical for maintaining immune tolerance. Recent studies have
confirmed their therapeutic suppressive potential to modulate immune responses in organ …
confirmed their therapeutic suppressive potential to modulate immune responses in organ …
The future of regulatory T cell therapy: promises and challenges of implementing CAR technology
YR Mohseni, SL Tung, C Dudreuilh, RI Lechler… - Frontiers in …, 2020 - frontiersin.org
Cell therapy with polyclonal regulatory T cells (Tregs) has been translated into the clinic and
is currently being tested in transplant recipients and patients suffering from autoimmune …
is currently being tested in transplant recipients and patients suffering from autoimmune …
Antigen-specific regulatory T cell therapy in autoimmune diseases and transplantation
C Selck, M Dominguez-Villar - Frontiers in immunology, 2021 - frontiersin.org
Regulatory T (Treg) cells are a heterogenous population of immunosuppressive T cells
whose therapeutic potential for the treatment of autoimmune diseases and graft rejection is …
whose therapeutic potential for the treatment of autoimmune diseases and graft rejection is …
Engrafting human regulatory T cells with a flexible modular chimeric antigen receptor technology
As regulatory T cells (Tregs) play a fundamental role in immune homeostasis their adoptive
transfer emerged as a promising treatment strategy for inflammation-related diseases …
transfer emerged as a promising treatment strategy for inflammation-related diseases …
Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor
KG MacDonald, RE Hoeppli, Q Huang… - The Journal of …, 2016 - Am Soc Clin Investig
Adoptive immunotherapy with regulatory T cells (Tregs) is a promising treatment for allograft
rejection and graft-versus-host disease (GVHD). Emerging data indicate that, compared with …
rejection and graft-versus-host disease (GVHD). Emerging data indicate that, compared with …
Building a CAR-Treg: going from the basic to the luxury model
I Rosado-Sanchez, MK Levings - Cellular Immunology, 2020 - Elsevier
Regulatory T cells (Tregs) control immune homeostasis and prevent exacerbated immune
responses, and can be used as cell therapy to dampen a variety of autoimmune or …
responses, and can be used as cell therapy to dampen a variety of autoimmune or …
The next frontier of regulatory T cells: Promising immunotherapy for autoimmune diseases and organ transplantations
Regulatory T cells (Tregs) are crucial in maintaining tolerance. Hence, Treg immunotherapy
is an attractive therapeutic option in autoimmune diseases and organ transplantations …
is an attractive therapeutic option in autoimmune diseases and organ transplantations …
Regulatory T cell therapy: current and future design perspectives
Regulatory T cells (Tregs) maintain immune equilibrium by suppressing immune responses
through various multistep contact dependent and independent mechanisms. Cellular …
through various multistep contact dependent and independent mechanisms. Cellular …
Preclinical assessment of antigen-specific chimeric antigen receptor regulatory T cells for use in solid organ transplantation
E Proics, M David, M Mojibian, M Speck… - Gene Therapy, 2023 - nature.com
A primary goal in transplantation medicine is the induction of a tolerogenic environment for
prevention of transplant rejection without the need for long-term pharmacological …
prevention of transplant rejection without the need for long-term pharmacological …