Single-domain antibody fragments, also known as VHHs or nanobodies, have opened
promising avenues in therapeutics and in exploration of intracellular processes. Because of …

The family of G protein-coupled receptors (GPCRs) is the largest class of membrane
proteins and an important drug target due to their role in many (patho) physiological …

G protein-coupled receptors (GPCRs) are the largest family of membrane receptors and
mediate the effects of a multitude of extracellular cues, such as hormones, neurotransmitters …

Human GnRH deficiency, both clinically and genetically, is a heterogeneous disorder
comprising of congenital GnRH deficiency with anosmia (Kallmann syndrome), or with …

Abstract I (RPM) presented “The Year In G Protein-Coupled Receptor Research” at ENDO
2009. I first described the diversity of ligands and the five families into which the …

The pivotal and diverse roles G protein-coupled receptors (GPCRs) play in physiology are
matched by the increasingly complex signal systems they activate. Over the past decade …

Ligand-induced activation of G protein–coupled receptors (GPCRs) is a key mechanism
permitting communication between cells and organs. Enormous progress has recently …

G protein-coupled receptors (GPCRs) constitute the largest superfamily of integral
membrane protein receptors. As signal detectors, the several 100 known GPCRs are …

Nanobodies are therapeutic proteins derived from the variable domain (VHH) of naturally
occurring heavy-chain antibodies. These VHH domains are the smallest functional …

The majority of hormones stimulates and mediates their signal transduction via G protein-
coupled receptors (GPCRs). The signal is transmitted into the cell due to the association of …