Pandrug-resistant Gram-negative bacteria: a systematic review of current epidemiology, prognosis and treatment options

S Karakonstantis, EI Kritsotakis… - Journal of Antimicrobial …, 2020 - academic.oup.com
Background The literature on the epidemiology, mortality and treatment of pandrug-resistant
(PDR) Gram-negative bacteria (GNB) is scarce, scattered and controversial. Objectives To …

Pandrug-resistant Gram-negative bacteria: the dawn of the post-antibiotic era?

ME Falagas, IA Bliziotis - International journal of antimicrobial agents, 2007 - Elsevier
The evolving problem of antimicrobial resistance in Pseudomonas aeruginosa,
Acinetobacter baumannii and Klebsiella pneumoniae has led to the emergence of clinical …

[HTML][HTML] Antibiotic therapy for pan-drug-resistant infections

MA Ozma, A Abbasi, M Asgharzadeh… - Le infezioni in …, 2022 - ncbi.nlm.nih.gov
Antibiotic resistance occurs when microorganisms resist the drugs used against the infection
caused by them and neutralize their effects over time using various mechanisms. These …

Recent advances in the pharmacological management of infections due to multidrug-resistant Gram-negative bacteria

DR Giacobbe, M Mikulska, C Viscoli - Expert review of clinical …, 2018 - Taylor & Francis
Introduction: The emergence and diffusion of multidrug-resistant Gram-negative bacteria
(MDR-GNB) is an unprecedented threat, with prevalences as high as 10–50% being …

[HTML][HTML] Current and potential therapeutic options for infections caused by difficult-to-treat and pandrug resistant gram-negative bacteria in critically ill patients

H Giamarellou, I Karaiskos - Antibiotics, 2022 - mdpi.com
Carbapenem resistance in Gram-negative bacteria has come into sight as a serious global
threat. Carbapenem-resistant Gram-negative pathogens and their main representatives …

[HTML][HTML] Trends, epidemiology, and management of multi-drug resistant gram-negative bacterial infections in the hospitalized setting

S Morris, E Cerceo - Antibiotics, 2020 - mdpi.com
The increasing prevalence of antibiotic resistance is a threat to human health, particularly
within vulnerable populations in the hospital and acute care settings. This leads to …

[HTML][HTML] Multidrug-resistant Gram-negative infections: what are the treatment options?

H Giamarellou, G Poulakou - Drugs, 2009 - Springer
The emergence of multidrug-resistant (MDR) Gram-negative bacilli creates a challenge in
the treatment of nosocomial infections. While the pharmaceutical pipeline is waning, two …

Predictors of mortality in patients with infections due to multi-drug resistant Gram negative bacteria: the study, the patient, the bug or the drug?

KZ Vardakas, PI Rafailidis, AA Konstantelias… - Journal of Infection, 2013 - Elsevier
OBJECTIVE: To study the predictors of mortality among patients with multi-drug resistant
Gram negative (MDRGN) infections and the role of MDRGN bacteria in the outcome of such …

Pandrug-resistant Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii infections: characteristics and outcome in a series of 28 patients

ME Falagas, PI Rafailidis, DK Matthaiou… - International journal of …, 2008 - Elsevier
We describe the characteristics and outcome of pandrug-resistant (PDR) Gram-negative
bacterial infections (23 Klebsiella pneumoniae isolates, 3 Pseudomonas aeruginosa and 3 …

Appraising contemporary strategies to combat multidrug resistant gram-negative bacterial infections–proceedings and data from the Gram-Negative Resistance …

MH Kollef, Y Golan, ST Micek, AF Shorr… - Clinical infectious …, 2011 - academic.oup.com
The emerging problem of antibiotic resistance, especially among Gram-negative bacteria
(GNB), has become a serious threat to global public health. Very few new antibacterial …