A novel mechanism for the loss of mRNA activity in lipid nanoparticle delivery systems
Lipid nanoparticle (LNP)-formulated mRNA vaccines were rapidly developed and deployed
in response to the SARS-CoV-2 pandemic. Due to the labile nature of mRNA, identifying …
in response to the SARS-CoV-2 pandemic. Due to the labile nature of mRNA, identifying …
Recent advances in site-specific lipid nanoparticles for mRNA delivery
The success of mRNA vaccines during the COVID-19 pandemic has greatly accelerated the
development of mRNA therapy. mRNA is a negatively charged nucleic acid that serves as a …
development of mRNA therapy. mRNA is a negatively charged nucleic acid that serves as a …
Lipid nanoparticle delivery systems to enable mRNA-based therapeutics
SC Semple, R Leone, CJ Barbosa, YK Tam, PJC Lin - Pharmaceutics, 2022 - mdpi.com
The world raced to develop vaccines to protect against the rapid spread of SARS-CoV-2
infection upon the recognition of COVID-19 as a global pandemic. A broad spectrum of …
infection upon the recognition of COVID-19 as a global pandemic. A broad spectrum of …
Mechanistic studies of an automated lipid nanoparticle reveal critical pharmaceutical properties associated with enhanced mRNA functional delivery in vitro and in …
Recently, lipid nanoparticles (LNPs) have attracted attention due to their emergent use for
COVID‐19 mRNA vaccines. The success of LNPs can be attributed to ionizable lipids, which …
COVID‐19 mRNA vaccines. The success of LNPs can be attributed to ionizable lipids, which …
Development of a high-throughput platform for screening lipid nanoparticles for mRNA delivery
L Cui, S Pereira, S Sonzini, S van Pelt, SM Romanelli… - Nanoscale, 2022 - pubs.rsc.org
mRNA lipid nanoparticles (LNPs) are at the forefront of nucleic acid intracellular delivery, as
exemplified by the recent emergency approval of two mRNA LNP-based COVID-19 …
exemplified by the recent emergency approval of two mRNA LNP-based COVID-19 …
A Unified Strategy to Improve Lipid Nanoparticle Mediated mRNA Delivery Using Adenosine Triphosphate
A central goal of chemical and drug delivery sciences is to maximize the therapeutic efficacy
of a given drug at the lowest possible dose. Here, we report a generalizable strategy that …
of a given drug at the lowest possible dose. Here, we report a generalizable strategy that …
[HTML][HTML] Lipid nanoparticles for mRNA delivery
Messenger RNA (mRNA) has emerged as a new category of therapeutic agent to prevent
and treat various diseases. To function in vivo, mRNA requires safe, effective and stable …
and treat various diseases. To function in vivo, mRNA requires safe, effective and stable …
Leveraging biological buffers for efficient messenger RNA delivery via lipid nanoparticles
Lipid nanoparticles containing messenger RNA (mRNA-LNPs) have launched to the
forefront of nonviral delivery systems with their realized potential during the COVID-19 …
forefront of nonviral delivery systems with their realized potential during the COVID-19 …
Lyophilization provides long-term stability for a lipid nanoparticle-formulated, nucleoside-modified mRNA vaccine
Lipid nanoparticle (LNP)-formulated nucleoside-modified mRNA vaccines have proven to be
very successful in the fight against the coronavirus disease 2019 (COVID-19) pandemic …
very successful in the fight against the coronavirus disease 2019 (COVID-19) pandemic …
Throughput-scalable manufacturing of SARS-CoV-2 mRNA lipid nanoparticle vaccines
SJ Shepherd, X Han, AJ Mukalel… - Proceedings of the …, 2023 - National Acad Sciences
Lipid nanoparticles (LNPs) are a potent delivery technology that have made it possible for
the recent clinical breakthroughs in mRNA therapeutics and vaccines. A key challenge to the …
the recent clinical breakthroughs in mRNA therapeutics and vaccines. A key challenge to the …