Mutations in cancer-associated genes drive tumour outgrowth, but our knowledge of the
timing of driver mutations and subsequent clonal dynamics is limited,–. Here, using whole …

Mutations in cancer-associated genes drive tumour outgrowth. However, the timing of driver
mutations and dynamics of clonal expansion that lead to human cancers are largely …

Chronic myeloproliferative neoplasms (MPNs) are a group of related conditions
characterized by the overproduction of cells from one or more myeloid lineages. More than …

Background Cancers result from the accumulation of somatic mutations, and their properties
are thought to reflect the sum of these mutations. However, little is known about the effect of …

Polycythemia vera, essential thrombocythemia and primary myelofibrosis are
myeloproliferative neoplasms (MPN) characterized by multilineage clonal hematopoiesis …

Some cancers originate from a single mutation event in a single cell. Blood cancers known
as myeloproliferative neoplasms (MPNs) are thought to originate when a driver mutation is …

Genome-wide association studies have identified a number of new disease susceptibility
loci that represent haplotypes defined by numerous SNPs. SNPs within a disease …

Tumor heterogeneity presents a challenge for inferring clonal evolution and driver gene
identification. Here, we describe a method for analyzing the cancer genome at a single-cell …

Myeloid malignancies, including acute myeloid leukaemia (AML), arise from the expansion
of haematopoietic stem and progenitor cells that acquire somatic mutations. Bulk molecular …

Myeloproliferative neoplasms (MPNs) are a group of clonal disorders characterized by
aberrant hematopoietic proliferation and an increased tendency toward leukemic …