The data landscape in preclinical safety assessment is fundamentally changing because of
not only emerging new data types, such as human systems biology, or real-world data …

eTRANSAFE: data science to empower translational safety assessment Skip to main content
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Early de-risking of drug targets and chemistry is essential to provide drug projects with the
best chance of success. Target safety assessments (TSAs) use target biology, gene and …

Introduction: The goal of early predictive safety assessment (PSA) is to keep compounds
with detectable liabilities from progressing further in the pipeline. Such compounds …

The development of new medicines is a long and expensive process. Despite growing
efforts in R&D over the last decades, attrition rate due to safety issues (especially cardiac …

Interventional pharmacology is one of medicine's most potent weapons against disease.
These drugs, however, can result in damaging side effects and must be closely monitored …

eTRANSAFE is a research project funded within the Innovative Medicines Initiative (IMI),
which aims at developing integrated databases and computational tools (the eTRANSAFE …

Safety pharmacology is essential throughout the spectrum of drug discovery and
development. Prior to first-in-human studies, safety pharmacology assays, tests, and models …

Drug safety remains a high profile issue at a time when the cost and time required to
develop a new drug are at an all time high. Balancing risk against the expected clinical …

The Predictive Safety Testing Consortium and the Coalition Against Major Diseases | Nature
Reviews Drug Discovery Skip to main content Thank you for visiting nature.com. You are using …