Glycogen synthase kinase 3 beta alters anxiety-, depression-, and addiction-related behaviors and neuronal activity in the nucleus accumbens shell

EJ Crofton, MN Nenov, Y Zhang, F Scala, SA Page… - …, 2017 - Elsevier
Psychiatric disorders such as anxiety, depression and addiction are often comorbid brain
pathologies thought to share common mechanistic biology. As part of the cortico-limbic …

Glycogen synthase kinase 3β in the nucleus accumbens core is critical for methamphetamine‐induced behavioral sensitization

C Xu, J Wang, P Wu, Y Xue, W Zhu, Q Li… - Journal of …, 2011 - Wiley Online Library
J. Neurochem.(2011) 10.1111/j. 1471‐4159.2011. 07281. x Abstract As a ubiquitous
serine/threonine protein kinase, glycogen synthase kinase 3β (GSK‐3β) has been …

Glycogen synthase kinase 3 beta regulates ethanol consumption and is a risk factor for alcohol dependence

A van der Vaart, X Meng, MS Bowers… - …, 2018 - nature.com
Understanding how ethanol actions on brain signal transduction and gene expression lead
to excessive consumption and addiction could identify new treatments for alcohol …

Glycogen synthase kinase 3β in the nucleus accumbens core mediates cocaine‐induced behavioral sensitization

C Xu, J Wang, P Wu, W Zhu, Q Li, Y Xue… - Journal of …, 2009 - Wiley Online Library
Glycogen synthase kinase 3β (GSK‐3β) is a ubiquitous serine/threonine protein kinase
involved in a number of signaling pathways. Previous studies have demonstrated a role for …

Chronic mild stress alters synaptic plasticity in the nucleus accumbens through GSK3β-dependent modulation of Kv4. 2 channels

G Aceto, C Colussi, L Leone, S Fusco… - Proceedings of the …, 2020 - National Acad Sciences
Although major depressive disorder (MDD) is highly prevalent, its pathophysiology is poorly
understood. Recent evidence suggests that glycogen-synthase kinase 3β (GSK3β) plays a …

Targeting glycogen synthase kinase-3 in the CNS: implications for the development of new treatments for mood disorders

TD Gould, AM Picchini, H Einat… - Current drug targets, 2006 - ingentaconnect.com
There exists an immediate need to develop novel medications for the treatment of mood
disorders such as bipolar disorder and depression. Initial interest in glycogen synthase …

Glycogen synthase kinase 3 regulates N-methyl-D-aspartate receptor channel trafficking and function in cortical neurons

P Chen, Z Gu, W Liu, Z Yan - Molecular pharmacology, 2007 - ASPET
Emerging evidence has suggested that glycogen synthase kinase 3 (GSK-3) is a key
regulatory kinase involved in a plethora of processes in the nervous system, including …

GSK-3β deletion in dentate gyrus excitatory neuron impairs synaptic plasticity and memory

E Liu, AJ Xie, Q Zhou, M Li, S Zhang, S Li, W Wang… - Scientific Reports, 2017 - nature.com
Increasing evidence suggests that glycogen synthase kinase-3β (GSK-3β) plays a crucial
role in neurodegenerative/psychiatric disorders, while pan-neural knockout of GSK-3β also …

Cocaine-induced hyperactivity and sensitization are dependent on GSK3

JS Miller, RJ Tallarida, EM Unterwald - Neuropharmacology, 2009 - Elsevier
Glycogen synthase kinase 3 (GSK3) is a critical mediator of many intracellular signaling
systems. The activity of GSK3 is regulated by several kinases, with inactivation occurring via …

Decrease of GSK 3β phosphorylation in the rat nucleus accumbens core enhances cocaine‐induced hyper‐locomotor activity

WY Kim, JK Jang, JW Lee, H Jang… - Journal of …, 2013 - Wiley Online Library
Glycogen synthase kinase 3β (GSK 3β), which is abundantly present in the brain, is known
to contribute to psychomotor stimulant‐induced locomotor behaviors. However, most studies …