Glycogen synthase kinase 3 beta alters anxiety-, depression-, and addiction-related behaviors and neuronal activity in the nucleus accumbens shell
Psychiatric disorders such as anxiety, depression and addiction are often comorbid brain
pathologies thought to share common mechanistic biology. As part of the cortico-limbic …
pathologies thought to share common mechanistic biology. As part of the cortico-limbic …
Glycogen synthase kinase 3β in the nucleus accumbens core is critical for methamphetamine‐induced behavioral sensitization
C Xu, J Wang, P Wu, Y Xue, W Zhu, Q Li… - Journal of …, 2011 - Wiley Online Library
J. Neurochem.(2011) 10.1111/j. 1471‐4159.2011. 07281. x Abstract As a ubiquitous
serine/threonine protein kinase, glycogen synthase kinase 3β (GSK‐3β) has been …
serine/threonine protein kinase, glycogen synthase kinase 3β (GSK‐3β) has been …
Glycogen synthase kinase 3 beta regulates ethanol consumption and is a risk factor for alcohol dependence
A van der Vaart, X Meng, MS Bowers… - …, 2018 - nature.com
Understanding how ethanol actions on brain signal transduction and gene expression lead
to excessive consumption and addiction could identify new treatments for alcohol …
to excessive consumption and addiction could identify new treatments for alcohol …
Glycogen synthase kinase 3β in the nucleus accumbens core mediates cocaine‐induced behavioral sensitization
C Xu, J Wang, P Wu, W Zhu, Q Li, Y Xue… - Journal of …, 2009 - Wiley Online Library
Glycogen synthase kinase 3β (GSK‐3β) is a ubiquitous serine/threonine protein kinase
involved in a number of signaling pathways. Previous studies have demonstrated a role for …
involved in a number of signaling pathways. Previous studies have demonstrated a role for …
Chronic mild stress alters synaptic plasticity in the nucleus accumbens through GSK3β-dependent modulation of Kv4. 2 channels
Although major depressive disorder (MDD) is highly prevalent, its pathophysiology is poorly
understood. Recent evidence suggests that glycogen-synthase kinase 3β (GSK3β) plays a …
understood. Recent evidence suggests that glycogen-synthase kinase 3β (GSK3β) plays a …
Targeting glycogen synthase kinase-3 in the CNS: implications for the development of new treatments for mood disorders
There exists an immediate need to develop novel medications for the treatment of mood
disorders such as bipolar disorder and depression. Initial interest in glycogen synthase …
disorders such as bipolar disorder and depression. Initial interest in glycogen synthase …
Glycogen synthase kinase 3 regulates N-methyl-D-aspartate receptor channel trafficking and function in cortical neurons
P Chen, Z Gu, W Liu, Z Yan - Molecular pharmacology, 2007 - ASPET
Emerging evidence has suggested that glycogen synthase kinase 3 (GSK-3) is a key
regulatory kinase involved in a plethora of processes in the nervous system, including …
regulatory kinase involved in a plethora of processes in the nervous system, including …
GSK-3β deletion in dentate gyrus excitatory neuron impairs synaptic plasticity and memory
Increasing evidence suggests that glycogen synthase kinase-3β (GSK-3β) plays a crucial
role in neurodegenerative/psychiatric disorders, while pan-neural knockout of GSK-3β also …
role in neurodegenerative/psychiatric disorders, while pan-neural knockout of GSK-3β also …
Cocaine-induced hyperactivity and sensitization are dependent on GSK3
JS Miller, RJ Tallarida, EM Unterwald - Neuropharmacology, 2009 - Elsevier
Glycogen synthase kinase 3 (GSK3) is a critical mediator of many intracellular signaling
systems. The activity of GSK3 is regulated by several kinases, with inactivation occurring via …
systems. The activity of GSK3 is regulated by several kinases, with inactivation occurring via …
Decrease of GSK 3β phosphorylation in the rat nucleus accumbens core enhances cocaine‐induced hyper‐locomotor activity
WY Kim, JK Jang, JW Lee, H Jang… - Journal of …, 2013 - Wiley Online Library
Glycogen synthase kinase 3β (GSK 3β), which is abundantly present in the brain, is known
to contribute to psychomotor stimulant‐induced locomotor behaviors. However, most studies …
to contribute to psychomotor stimulant‐induced locomotor behaviors. However, most studies …