Parkinsonian beta oscillations in the external globus pallidus and their relationship with subthalamic nucleus activity

N Mallet, A Pogosyan, LF Márton, JP Bolam… - Journal of …, 2008 - Soc Neuroscience
Inappropriately synchronized beta (β) oscillations (15–30 Hz) in the subthalamic nucleus
(STN) accompany movement difficulties in idiopathic Parkinson's disease (PD). The cellular …

Move to the rhythm: oscillations in the subthalamic nucleus–external globus pallidus network

MD Bevan, PJ Magill, D Terman, JP Bolam… - Trends in …, 2002 - cell.com
Recent anatomical, physiological and computer modeling studies have revealed that
oscillatory processes at the levels of single neurons and neuronal networks in the …

Effective connectivity of the subthalamic nucleus–globus pallidus network during Parkinsonian oscillations

AJ Nevado‐Holgado, N Mallet, PJ Magill… - The Journal of …, 2014 - Wiley Online Library
Key points The firing of subthalamic nucleus (STN) neurons and two types of external globus
pallidus (GP) neuron becomes excessively and rhythmically synchronised in Parkinsonism …

Disrupted dopamine transmission and the emergence of exaggerated beta oscillations in subthalamic nucleus and cerebral cortex

N Mallet, A Pogosyan, A Sharott… - Journal of …, 2008 - Soc Neuroscience
In the subthalamic nucleus (STN) of Parkinson's disease (PD) patients, a pronounced
synchronization of oscillatory activity at beta frequencies (15–30 Hz) accompanies …

Parkinsonism alters Beta burst dynamics across the basal ganglia–motor cortical network

Y Yu, DE Sanabria, J Wang, CM Hendrix… - Journal of …, 2021 - Soc Neuroscience
Elevated synchronized oscillatory activity in the beta band has been hypothesized to be a
pathophysiological marker of Parkinson's disease (PD). Recent studies have suggested that …

Dysregulation of external globus pallidus‐subthalamic nucleus network dynamics in parkinsonian mice during cortical slow‐wave activity and activation

RF Kovaleski, JW Callahan, M Chazalon… - The Journal of …, 2020 - Wiley Online Library
Key points Reciprocally connected GABAergic external globus pallidus (GPe) and
glutamatergic subthalamic nucleus (STN) neurons form a key network within the basal …

Pallidal deep-brain stimulation disrupts pallidal beta oscillations and coherence with primary motor cortex in Parkinson's disease

DD Wang, C de Hemptinne, S Miocinovic… - Journal of …, 2018 - Soc Neuroscience
In Parkinson's disease (PD), subthalamic nucleus beta band oscillations are decreased by
therapeutic deep-brain stimulation (DBS) and this has been proposed as important to the …

Pathological subthalamic nucleus oscillations in PD: can they be the cause of bradykinesia and akinesia?

M Weinberger, WD Hutchison, JO Dostrovsky - Experimental neurology, 2009 - Elsevier
There is growing evidence that Parkinson's disease (PD) is associated with pathological
synchronous oscillatory activity in the basal ganglia. These synchronized oscillations …

Globus pallidus neurons dynamically regulate the activity pattern of subthalamic nucleus neurons through the frequency-dependent activation of postsynaptic GABAA …

NE Hallworth, MD Bevan - Journal of Neuroscience, 2005 - Soc Neuroscience
Reciprocally connected GABAergic neurons of the globus pallidus (GP) and glutamatergic
neurons of the subthalamic nucleus (STN) are a putative generator of pathological rhythmic …

Conditions for the generation of beta oscillations in the subthalamic nucleus–globus pallidus network

AJN Holgado, JR Terry, R Bogacz - Journal of Neuroscience, 2010 - Soc Neuroscience
The advance of Parkinson's disease is associated with the existence of abnormal
oscillations within the basal ganglia with frequencies in the beta band (13–30 Hz). While the …