PURPOSE To review the most important recent advances in clinical trials and biologic
studies within the growing field of chemoprevention. METHODS The most critical methods …

In the relatively brief history of cancer chemoprevention, hundreds of chemoprevention
studies have been reported. The vast majority were uncontrolled studies that were designed …

Cancer chemoprevention is the use of specific natural or synthetic substances with the
objective of reversing, suppressing, or preventing carcinogenic progression to invasive …

Head and neck cancer is a major worldwide health problem; it has been estimated that
approximately 900 000 people were diagnosed with this disease in 1995. Patients are …

Clinical chemoprevention trials of more than 30 agents and agent combinations are now in
progress or being planned. The most advanced agents are well known and are in large …

Chemoprevention has been shown to be an extremely promising approach to the prevention
of invasive cancer. Through the identification of chemopreventive agents that inhibit or …

Tamimi RM, Lagiou P, Adami H‐O, Trichopoulos D (Harvard School of Public Health,
Boston, MA, USA; University of Athens Medical School, Goudi, Athens, Greece; and …

The incidence and mortality rates for most of the common forms of cancer are still
unacceptably high. This stark fact in itself is a strong argument for further research, both …

Chemoprevention of cancer is reviewed from the viewpoints of action mechanisms and
methodology of clinical trials in order to introduce promising agents discovered by in vitro …

Chemoprevention drug development has the goal of identifying safe and effective
chemopreventive agents for clinical use. Several distinctive strategies are pursued in …