Both selenium deficiency and excess impair male reproductive system via inducing oxidative stress-activated PI3K/AKT-mediated apoptosis and cell proliferation …

Z Xu, M Liu, QJ Niu, YX Huang, L Zhao, XG Lei… - Free Radical Biology …, 2023 - Elsevier
Selenium (Se) deficiency or excess impairs testicular development and spermatogenesis,
while the underlying mechanisms in this regard remain unclear. This study was designed to …

Dietary selenium excess affected spermatogenesis via DNA damage and telomere-related cell senescence and apoptosis in mice

Y Zhang, J Liu, X Li, G Zhou, Y Sang, M Zhang… - Food and Chemical …, 2023 - Elsevier
Selenium (Se) is a vital microelement for spermatogenesis and male fertility. The aim of this
study was to investigate the effects of Se on the male reproductive function and possible …

Dietary selenium variation-induced oxidative stress modulates CDC2/cyclin B1 expression and apoptosis of germ cells in mice testis

N Kaushal, MP Bansal - The Journal of nutritional biochemistry, 2007 - Elsevier
Oxidative stress has been linked with apoptosis in germ cells and with male infertility.
However, the molecular mechanism of oxidative-stress-mediated apoptosis in germ cells …

Alterations in selenium status influences reproductive potential of male mice by modulation of transcription factor NFκB

S Shalini, MP Bansal - Biometals, 2007 - Springer
Selenium (Se), an essential dietary trace element, is required for the maintenance of male
fertility. In order to study its role in spermatogenesis, Balb/c mice with different Se status (Se …

Role of selenium in regulation of spermatogenesis: involvement of activator protein 1

S Shalini, MP Bansal - Biofactors, 2005 - Wiley Online Library
Selenium (Se) is involved in the process of male reproduction. Several studies have been
carried out to find the mechanism of Se action through identified selenoproteins. Especially …

Apoptosis induced by modulation in selenium status involves p38 MAPK and ROS: implications in spermatogenesis

P Ranawat, MP Bansal - Molecular and cellular biochemistry, 2009 - Springer
Selenium has been linked to cell survival and apoptosis. Apoptosis plays an important role
in spermatogenesis. Evidence suggests that reactive oxygen species induce apoptotic …

Diminished reproductive potential of male mice in response to selenium‐induced oxidative stress: Involvement of HSP70, HSP70‐2, and MSJ‐1

N Kaushal, MP Bansal - Journal of biochemical and molecular …, 2009 - Wiley Online Library
The oxidative stress imposed by nutritional variations in selenium (Se) has plausible role in
reproductive toxicology and affects the reproductive potential. Also, the expression of heat …

Role of selenium in spermatogenesis: differential expression of cjun and cfos in tubular cells of mice testis

S Shalini, MP Bansal - Molecular and cellular biochemistry, 2006 - Springer
Selenium (Se) is an essential dietary trace element, involved in the process of male
reproduction. Best known as an antioxidant, it acts through various selenoproteins viz …

Effect of selenium-induced oxidative stress on the cell kinetics in testis and reproductive ability of male mice

P Kaur, MP Bansal - Nutrition, 2005 - Elsevier
OBJECTIVE: The present study evaluated the role of experimental oxidative stress (induced
by feeding diets with different concentrations of selenium [Se], a trace nutrient and potent …

Co-operative effect of glutathione depletion and selenium induced oxidative stress on API and NFkB expression in testicular cells in vitro: insights to regulation of …

S Shalini, MP Bansal - Biological research, 2007 - SciELO Chile
Previous studies have shown that transcription factors, API and NFkB exert important roles in
the process by which selenium regulates spermatogenesis. Glutathione, an intracellular …