Amyotrophic lateral sclerosis (ALS) is the most common adult onset motor neuron disease
with no effective disease modifying therapies at present. Spinal cord degeneration is a …

Despite considerable involvement of the spinal cord in amyotrophic lateral sclerosis (ALS),
current biomarker research is primarily centred on brain imaging and CSF proteomics. In …

Amyotrophic lateral sclerosis (ALS) is characterized by progressive degeneration of upper
and lower motor neurons, with variable involvement of extramotor brain regions. Currently …

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease for which a precise
cause has not yet been identified. Standard CT or MRI evaluation does not demonstrate …

Introduction: Several neuroimaging techniques have been used to define in vivo markers of
pathological alterations underlying amyotrophic lateral sclerosis (ALS). Growing evidence …

Amyotrophic lateral sclerosis (ALS) is now recognised to be a heterogeneous
neurodegenerative syndrome of the motor system and its frontotemporal cortical …

In patients with ALS, conventional MR imaging is frequently noninformative, and its use has
been restricted to excluding other conditions that can mimic ALS. Conversely, the extensive …

Introduction: In the last decade, multiparametric magnetic resonance imaging (MRI) has
achieved tremendous advances in applications to amyotrophic lateral sclerosis (ALS) to …

Objective markers of disease sensitive to the clinical activity, symptomatic progression, and
underlying substrates of neurodegeneration are highly coveted in amyotrophic lateral …

Advanced magnetic resonance imaging (MRI) techniques hold the promise to capture upper
motor neuron loss and extramotor brain changes in amyotrophic lateral sclerosis (ALS) and …