The dynamic relation between stem cells and their niche governs self-renewal and
progenitor cell deployment. The chemokine CXCL12 (CXC motif ligand 12) and its signaling …

In the adult brain, neural progenitor cells (NPCs) reside in the subventricular zone (SVZ) of
the lateral ventricles, the dentate gyrus and the olfactory bulb. Following CNS insult, NPCs …

Research into multiple sclerosis (MS) has shown that cells purportedly important to myelin
repair within the CNS, namely neural stem cells (NSC) and oligodendrocyte progenitor cells …

Neural progenitor cell (NPC) migration is an essential process for brain development, adult
neurogenesis, and neuroregeneration after brain injury. Stromal cell-derived factor-1 (SDF …

Migration toward pathology is the first critical step in stem cell engagement during
regeneration. Neural stem cells (NSCs) migrate through the parenchyma along …

Chemotactic cytokines (chemokines) have been traditionally defined as small (10–14kDa)
secreted leukocyte chemoattractants. However, chemokines and their cognate receptors are …

Chemokine CXC ligand 12 (CXCL12), originally named stromal cell-derived factor-1 (SDF-
1), is a member of the CXC chemokine subfamily. CXCL12 is found to be expressed by all …

Background Ischemic stroke causes a multitude of brain damage. Neurovascular injury and
myelin sheath degradation are two manifestations of ischemic brain damage. Therapeutic …

The chemokine CXCL12 plays a vital role in regulating the development of the central
nervous system (CNS) by binding to its receptors CXCR4 and CXCR7. Recent studies …

Chemokine CXCL12 is widely expressed in the central nervous system and essential for the
proper functioning of human neural progenitor cells (hNPCs). Although CXCL12 is known to …