Cell excitability and its modulation by hormones and neurotransmitters involve the concerted
action of a large repertoire of membrane proteins, especially ion channels. Unique …

Ion channels are crucial components of cellular excitability and are involved in many
neurological diseases. This review focuses on the sodium leak, G protein-coupled receptors …

The sodium leak channel (NALCN) is essential for survival in mammals: NALCN mutations
are life-threatening in humans and knockout is lethal in mice. However, the basic functional …

Sodium plays a key role in determining the basal excitability of the nervous systems through
the resting" leak" Na+ permeabilities, but the molecular identities of the TTX-and Cs+ …

Persistently depolarizing sodium (Na+) leak currents enhance electrical excitability,. The ion
channel responsible for the major background Na+ conductance in neurons is the Na+ leak …

Extracellular K+, Na+, and Ca 2+ ions all influence the resting membrane potential of the
neuron. However, the mechanisms by which extracellular Na+ and Ca 2+ regulate basal …

The sodium leak channel nonselective protein (NALCN) is a regulator of the pacemaker
neurons that are responsible for rhythmic behavior (including respiration), maintaining the …

NALCN, a sodium leak channel expressed mainly in the central nervous system, is
responsible for the resting Na+ permeability that controls neuronal excitability. Dysfunctions …

The sodium leak channel, a Na+‐permeable, nonselective cation channel, is widely
expressed in the nervous system, contributing a basal Na+‐leak conductance and …

Resting membrane potential determines the excitability of the cell and is essential for the
cellular electrical activities. The NALCN channel mediates sodium leak currents, which …