Efficient clearance of apoptotic cells by phagocytosis, also known as efferocytosis, is
fundamental to developmental biology, organ physiology, and immunology. Macrophages …

A favorable outcome following acute bacterial infection depends on the ability of phagocytic
cells to be recruited and properly activated within injured tissues. Calcium (Ca 2+) is a …

Phagocytosis of large extracellular particles such as apoptotic bodies requires delivery of
the intracellular endosomal and lysosomal membranes to form plasmalemmal pseudopods …

Under physiological conditions, the widely expressed calcium-activated TRPM4 channel
conducts sodium into cells. This sodium influx depolarizes the plasma membrane and …

Acidification of macrophage phagosomes serves an important bactericidal function. We
show here that the redox-sensitive transient receptor potential (TRP) cation channel TRPM2 …

Reactive oxygen species (ROS) induce chemokines responsible for the recruitment of
inflammatory cells to sites of injury or infection. Here we show that the plasma membrane …

Monocytes are mononuclear phagocytes that can differentiate to a variety of cell fates under
the influence of their microenvironment and hardwired commitment. We found that inhibition …

Macrophage phagocytosis is critical for defense against pathogens. Whereas many steps of
phagocytosis involve ionic flux, the underlying ion channels remain ill defined. Here we …

Defects in the innate immune system in the lung with attendant bacterial infections contribute
to lung tissue damage, respiratory insufficiency, and ultimately death in the pathogenesis of …

We have recently shown that in macrophages proper operation of the survival pathways
phosphatidylinositol-3-kinase (PI3K)/AKT and nuclear factor kappa B (NFkB) has an …